小剂量胰岛素联合生长抑素治疗糖尿病酮症酸中毒合并急性胰腺炎的临床疗效

Clinical effect of low-dose insulin combined with somatostatin on diabetic ketoacidosis complicated with acute pancreatitis

目的探讨小剂量胰岛素联合生长抑素治疗糖尿病酮症酸中毒合并急性胰腺炎的临床疗效。方法选取高安市人民医院2018年2月—2019年9月收治的糖尿病酮症酸中毒伴急性胰腺炎患者60例,按照随机数字表法分为对照组与观察组,各30例。对照组予以胰岛素治疗,观察组予以小剂量胰岛素联合生长抑素治疗。比较2组临床疗效,治疗前后血液淀粉酶、血糖、血酮体、三酰甘油,并观察2组不良反应发生情况。结果观察组治疗总有效率高于对照组(P<0.05)。治疗前2组血液淀粉酶、血糖、血酮体、三酰甘油比较,差异无统计学意义(P>0.05);治疗后观察组血液淀粉酶、血糖、血酮体、三酰甘油水平低于对照组(P<0.05)。2组呕吐加重、排便困难、头晕发生率比较,差异无统计学意义(P>0.05)。结论小剂量胰岛素联合生长抑素治疗糖尿病酮症酸中毒合并急性胰腺炎的临床疗效确切,可有效改善临床症状,且安全性较高。

Objective To investigate the clinical effect of low-dose insulin combined with somatostatin on diabetic ketoacidosis complicated with acute pancreatitis.Methods A total of 60 cases of patients with diabetic ketoacidosis complicated with acute pancreatitis were selected from February 2018 to September 2019 in Gaoan People’s Hospital,which were randomly divided into control group and observation group,each with 30 cases.The control group was treated with insulin,the observation group was treated with low-dose insulin combined with somatostatin.Clinical effect,blood amylase,blood glucose,blood ketone body and triacylglycerol before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results The total effective rate of observation group was higher than control group(P<0.05).Before treatment,there was no significant difference in blood amylase,blood glucose,blood ketone body and triglyceride between the two groups(P>0.05);after treatment,the levels of blood amylase,blood glucose,blood ketone body and triglyceride in the observation group were lower than control group(P<0.05).There was no significant difference in the incidence of vomiting,difficulty in defecation and dizziness between the two groups(P>0.05).Conclusion Low-dose insulin combined with somatostatin have an exact clinical effect for diabetic ketoacidosis complicated with acute pancreatitis,which can effectively improve clinical symptoms,and with high safety.