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甲状腺MALT 14例临床病理分析 被引量:1

Clinicopathological features of B-cell lymphoma in peripheral region of thyroid primary mucosa-associated lymphoid tissue: report of 14 cases with review of literature
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摘要 目的探讨甲状腺原发黏膜相关淋巴组织结外边缘区B细胞淋巴瘤(MALT)的临床病理特征。方法收集和分析14例甲状腺MALT临床病理资料,并文献复习。结果男性患者5例,女性患者9例,年龄35~75岁,平均年龄58.6岁。患者均表现为颈前肿大。显微镜下见肿瘤细胞形态多样,可见单核样B细胞及小淋巴细胞增生,胞质淡染,散在中心母细胞及免疫母细胞样细胞,半数病例可见浆细胞分化,多数病例出现典型"淋巴上皮病变"(12/14例),且可见滤泡植入现象(9例),3例局部出现大B细胞转化。4例周围见桥本甲状腺炎。随访8例患者均存活,2例为手术部分切除术后,6例行化疗、2例辅助放疗,2例未行放化疗,随访4个月~8年8个月,平均生存36个月,5年生存率100%。结论甲状腺MALT淋巴瘤罕见,部分与桥本甲状腺炎有关,预后较好。 Objective To investigate the clinicopathological characteristics of B-cell lymphoma in the peripheral region of thyroid primary mucosa-associated lymphoid tissue( MALT). Methods The clinicopathological data of 14 cases of thyroid MALT were collected and analyzed. Results Five male and 9 female patients aged from 35 to 75 years,with an average age of 58. 6 years. Microscopically,the tumor cells showed a variety of morphology,including mononuclear B cells, small lymphocytes, scattered central and immunoblastoid cells. A half of them had plasma cell differentiation. Typical lymphoepithelial lesions were seen in most cases( 12/14). Follicular implantation was seen in 9 patients,and local large B cell transformation was observed in 3 patients. Eight patients were followed up,and 6 cases received chemotherapy,two of them also received radiotherapy;2 cases did not receive chemoradiotherapy. All of patients survived during the follow-up period of 4 months to 8 years and 8 months,whose average survival time was 36 months. 5 year survival rate was 100%. Conclusion Thyroid MALTs are rare,partly related to Hashimoto’s thyroiditis,and the patients have a good prognosis.
作者 李秀君 宋欣 李杰 曹晨 王红群 石怀银 LI Xiu-jun;SONG Xin;LI Jie;CAO Chen;WANG Hong-qun;SHI Huai-yin(Department of Pathology,the First Medical Center of PLA General Hospital,Beijing 100853,China)
出处 《诊断病理学杂志》 2021年第4期252-255,共4页 Chinese Journal of Diagnostic Pathology
关键词 甲状腺黏膜相关淋巴组织 临床病理特征 预后 Thyroid mucosa-associated lymphoid tissue Clinicopathological features Prognosis
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