新生儿化脓性脑膜炎148例临床分析

Clinical Analysis of 148 Cases of Neonatal Purulent Meningitis

目的探讨新生儿化脓性脑膜炎的临床特点。方法分析148例新生儿化脓性脑膜炎的临床特点、实验室检查和病原学治疗。结果新生儿化脓性脑膜炎最常见症状为发热、呼吸系统改变、黄疸、抽搐。外周血最常见的改变为白细胞升高和超敏C反应蛋白(hs-CRP)水平升高。大肠埃希菌是最主要的病原菌。结论新生儿化脓性脑膜炎是新生儿严重感染性疾病之一,发病率及病死率高,应重视早期临床表现,尽早行病原学检测,根据病原菌药敏试验及临床经验合理选用抗生素,以降低病死率。

Objective To explore the clinical futures of neonatal purulent meningitis.Methods The clinical futures,laboratory findings and pathogens were analyzed in 148 neonatal purulent meningitis.Results The most common symptoms of neonatal purulent meningitis were fever,respiratory system changes,jaundice,convulsion.The most common peripheral blood changes were increased leukocyte and high level of high-sensitivity C-reaction protein(hs-CRP).Escherichia coli was the most important pathogen.Conclusion Neonatal purulent meningitis is one of severe infective diseases in newborn.Its morbidity and mortality are high.The early clinical characteristics should be emphasized,etiological detection should be performed timely,according to pathogenic bacteria drug sensitive test and clinical experiences,appropriate antibiotics should be used to reduce the fatality rate.