大肠癌患者术前M分期与其临床特征及预后关系的研究

Study on the relationship between M‑stage before operation and clinical characteristics and prognosis of colorectal cancer patients

目的探讨术前M分期与大肠癌患者临床特征及预后的关系,为大肠癌的预防及临床治疗提供理论依据。方法本文采用回顾性队列研究的科研设计,回顾性选取2011年8月至2014年8月在昆明医科大学第一附属医院经手术治疗且病理证实为大肠癌的患者,收集患者的临床资料并对其进行随访,至患者死亡、失访或最后一次随访时间为终点,截止时间为2019年8月31日。结果纳入随访147例,按TNM分期分为两组,其中M0期组106例、M1期组41例,与M0期组比较,M1期组合并胆道病史、合并阑尾病史、肝转移的比例均较高(均P<0.05);两组的发病年龄段构成不同,M0期组60~79岁、80~99岁占多数,M1期组20~39岁、40~59岁占多数。结论作为大肠癌患者的独立预后因素,术前M分期可作为预测大肠癌患者预后的重要指标,而胆道病史、阑尾病史、肝转移与大肠癌患者术后预后情况相关。

Objective To explore the relationship between preoperative M stage and clinical features and prognosis of colorectal cancer patients in order to provide theoretical basis for the prevention and clinical treatment.Methods The study is a retrospective cohort study.From August 2011 to August 2014 cases of colorectal cancer which confirmed by surgery and pathology were selected from the hospital.We collected the clinical data and follow-up of patients until patients died,lost to follow-up or to the deadline.The deadline is August 31,2019.Results A total of 147 patients were included in this study.They were divided into 2 groups according to TNM stage,including 106 patients in stage M0 group and 41 patients in Stage M1 group.Compared with M0 group,the incidence of biliary tract disease,appendiceal disease and liver metastasis were higher in M1 Group(P<0.05).The age of onset was different in the two groups.M0 group aged 60-79 years and 80-99 years accounting for the majority,while M1 group aged 20-39 years and 40-59 years accounting for the majority.Conclusion As an independent prognostic factor for patients with colorectal cancer,preoperative M stage is an important prognostic indicator for predicting the prognosis of patients with colorectal cancer,while the history of biliary tract,history of appendix and liver metastasis are related to the postoperative prognosis of patients with colorectal cancer.