摘要
The emergence of multi-drug resistance makes bacterial infection a major threat to public health and economy.The formation of bacterial biofilms is one of the main reasons of bacterial resistance.The complexity of chemical composition and physical structure makes the elimination of mature biofilms a difficult problem.The highly antibiotic resistant property of biofilms urgently calls for potent antimicrobial agents and novel antibiofilm strategies.Researchers have made a lot of efforts in this field.Here we review the current strategies to eliminate mature biofilms and progress in related drug delivery nanosystems,with the aim of inspiring researchers to design new antibiofilm systems.
基金
the Natural Science Foundation of Shanghai(18ZR1410300)
the National Natural Science Foundation of China(No.21861162010,21774031,31800801)
Program of Shanghai Academic/Technology Research Leader(20XD1421400)
the National Key Research and Development Program of China(2016YFC1100401)
Research Program of State Key Laboratory of Bioreactor Engineering
the Fundamental Research Funds for the Central Universities(No.22221818014,50321041917001)。
