成人新诊断高危低级别胶质瘤术后治疗的现状及争议

Current status and controversies of postoperative treatment of newly diagnosed highrisk low-grade gliomas in adults

高危低级别胶质瘤为世界卫生组织(WHO)Ⅱ级是一组起源于中枢神经系统胶质细胞的异质性肿瘤。手术通常作为首选的治疗方法,然而术后最佳治疗方法暂无共识。术后放疗、化疗可以提高部分患者的局部控制率和总生存率(overall survival,OS),但对于高危低级别胶质瘤术后最佳放疗时机、放疗的剂量、化疗药物的选择、靶向治疗和免疫治疗等目前尚存争议。本文就国内外文献进行归纳总结,并对高危低级别胶质瘤术后辅助治疗的现状及争议进行探讨。

High-risk low-grade gliomas(WHOⅡgrade)are a group of heterogeneous tumors originating from glial cells in the central nervous system.Surgery is usually the first choice of treatment,but the best postoperative treatment is still inconclusive.Studies have shown that postoperative radiotherapy and chemotherapy can improve the local control rate and overall survival time of some patients.However,there are still disputes about the best time for postoperative radiotherapy,the dose of radiotherapy,the choice of chemotherapeutic drugs,targeted therapy and immunotherapy for high-risk low-grade gliomas.This paper summarizes literatures at home and abroad,and discusses the current status and controversies of postoperative adjuvant therapy for high-risk low-grade gliomas.