最有前途的肌少症生化检查方法:D_(3)-肌酸稀释法

Most promising biochemical test for sarcopenia:D_(3)-creatine dilution

肌少症是一种与增龄有关,进行性、全身性的骨骼肌疾病。目前肌少症相关研究几乎都是以测量瘦体质量或无脂肪体质量来替代骨骼肌质量,而不是真正的直接测量骨骼肌质量。生物阻抗分析(BIA)、双能X线吸收法(DXA)、计算机断层扫描(CT)、磁共振成像(MRI)、超声检查等肌少症相关的常用骨骼肌测量方法各有缺陷,他们多数属于间接测量纯解剖骨骼肌质量的指标,少数属于直接测量纯解剖肌量指标。D3-肌酸稀释法是目前最有前途的直接测量功能性肌量方法,该方法可以直接准确测量肌酸池大小和骨骼肌质量,反映骨骼肌功能,有望成为肌少症最有前途的生化检查方法,弥补目前常用方法存在的缺陷。

Sarcopenia is an age-associated,progressive and generalised skeletal muscle disorder.However,almost every study about sarcopenia is concerning on measurement of lean body mass or far-free mass rather than skeletal muscle mass.Bioelectrical impedance analysis(BIA),dual energy X-ray absorptiometry(DXA),computed tomography(CT),magnetic resonance imaging(MRI),and ultrasound examination are all commonly used methods of skeletal muscle measurement for sarcopenia,but all of them are flawed.Most of them are indirect measurement of simple indexes for anatomical skeletal muscle mass,and a few are direct measurement of index as anatomical muscle mass.D_(3)-creatine dilution,however,is the most promising approach to directly measuring skeletal muscle mass.It provides a direct and accurate measurement of creatine pool size and skeletal muscle mass,and also can reflect skeletal muscle function.It is expected to be the most promising biochemical examination for sarcopenia,which can make up for the defects of the current common methods.