克洛己新干混悬剂和阿莫西林-克拉维酸钾治疗小儿急性细菌性下呼吸道感染的随机对照研究

A Randomized Controlled Study of Clohexine Dry Suspension and Amoxicillin-clavulanate Potassium in the Treatment of Children with Acute Bacterial Lower Respiratory Tract Infections

目的观察分析克洛己新干混悬剂和阿莫西林-克拉维酸钾治疗小儿急性细菌性下呼吸道感染的随机对照研究。方法方便选取2018年8月—2019年10月在该院收治的88例急性细菌性下呼吸道感染患儿作为研究对象,采取随机分组法将所有患儿分为两组,对照组与研究组各44例,对照组患儿采取阿莫西林-克拉维酸钾治疗,研究组患儿采取克洛己新干混悬剂治疗,分析两组患儿的临床疗效、症状缓解与不良反应发生率。结果研究组患儿治疗总有效率为95.45%,对照组患儿治疗总有效率为81.82%,研究组患儿治疗总效率明显高于对照组,差异有统计学意义(χ^(2)=4.062,P<0.05)。研究组患儿咳嗽缓解时间、退热时间、体感不适缓解时间分别为(5.25±1.25)、(1.45±0.76)、(4.22±0.90)d,对照组患儿咳嗽缓解时间、退热时间、体感不适缓解时间(6.15±1.42)、(1.90±0.82)、(5.12±0.95),研究组均短于对照组,差异有统计学意义(t=3.156、2.670、4.562,P<0.05)。两组患儿均未出现严重的不良反应,两组患儿不良反应发生率比较差异无统计学意义(χ^(2)=0.386,P>0.05)。结论对小儿急性细菌性下呼吸道感染患儿采取克洛己新干混悬剂治疗,效果显著,不良反应发生率低,安全可靠,值得临床推广。

Objective To observe and analyze a randomized controlled study of clohexine dry suspension and amoxicillin-clavulanate potassium in the treatment of acute bacterial lower respiratory tract infections in children.Methods A total of 88 children with acute bacterial lower respiratory tract infection who were admitted to the hospital from August 2018 to October 2019 were conveniently selected as the research objects.All the children were divided into two groups by randomization.They were divided into two groups,the control group and the study group,with 44 cases each group,children in the control group were treated with amoxicillin-clavulanate potassium,and the children in the study group were treated with clohexine dry suspension.The clinical efficacy,symptom relief and incidence of adverse reactions of the two groups were analyzed.Results The total effective rate of treatment for children in the study group was 95.45%,and the total effective rate of treatment for children in the control group was 81.82%.The total treatment efficiency of children in the study group was significantly higher than that of the control group,and the difference was statistically significant(χ^(2)=4.062,P<0.05)).The cough remission time,fever remission time,and somatosensory discomfort remission time of children in the study group were(5.25±1.25)d,(1.45±0.76)d,and(4.22±0.90)d,respectively.The cough remission time,fever remission time,somatosensory discomfort relief time of the control group were(6.15±1.42)d,(1.90±0.82)d,(5.12±0.95)d,the study group was shorter than the control group,the difference was statistically significant(t=3.156,2.670,4.562,P<0.05).There were no serious adverse reactions in the two groups of children,and there was no statistically significant difference in the incidence of adverse reactions between the two groups(χ^(2)=0.386,P>0.05).Conclusion The treatment of children with acute bacterial lower respiratory tract infections with clohexine dry suspension is effective,with low incidence of adverse reactions,safe and reliable,and is worthy of clinical promotion.