鼻渊通窍颗粒联合西替利嗪对过敏性鼻炎患儿嗜酸性粒细胞比例及复发的影响

Effect of Biyuantongqiao Granules Combined with Cetirizine on Eosinophil Proportion and Recurrence in Children with Allergic Rhinitis

目的探讨鼻渊通窍颗粒联合西替利嗪对过敏性鼻炎患儿嗜酸性粒细胞比例及复发的影响。方法回顾性收集该院2018年2月—2019年2月收治的103例过敏性鼻炎患儿临床资料,将采用西替利嗪治疗的50例患儿纳入A组,将采用鼻渊通窍颗粒联合西替利嗪治疗的53例患儿纳入B组。治疗1个月后,比较两组临床疗效、嗜酸性粒细胞比例、症状体征积分、不良反应及1年内复发情况。结果B组总有效率为96.23%,较A组的82.00%高,差异有统计学意义(χ^(2)=5.459,P=0.020);B组治疗后嗜酸性粒细胞比例为(11.35±2.84)%,较A组(16.84±3.87)%低,差异有统计学意义(t=8.241,P<0.001);B组治疗后喷嚏、流涕、鼻痒、鼻塞、体征积分分别为(1.00±0.24)分、(0.50±0.37)分、(0.50±0.41)分、(1.00±0.28)分、(0.50±0.47)分,均较A组(1.50±0.28)分、(1.40±0.28)分、(1.20±0.33)分、(1.60±0.35)分、(1.00±0.55)分低,差异有统计学意义(t=9.748、13.858、9.511、9.634、4.969,P<0.001);B组不良反应发生率为3.77%,略低于A组的8.00%,差异无统计学意义(χ^(2)=0.244,P=0.360);B组1年内复发率为5.88%,较A组的31.71%低,差异有统计学意义(χ^(2)=10.551,P=0.001)。结论鼻渊通窍颗粒联合西替利嗪治疗过敏性鼻炎患儿效果较好,可有效降低嗜酸性粒细胞比例,改善临床症状、体征,降低复发率,且安全性较好,疗效显著。

Objective To investigate the effect of Biyuantongqiao Granules combined with cetirizine on the proportion of eosinophils and recurrence in children with allergic rhinitis.Methods The clinical data of 103 children with allergic rhinitis admitted in the hospital from February 2018 to February 2019 were retrospectively collected.50 children who were treated with cetirizine were included in group A,and the combination of Biyuantongqiao granules was used 53 children treated with cetirizine were included in group B.After 1 month of treatment,the clinical efficacy,eosinophil ratio,symptom and sign score,adverse reactions and recurrence within 1 year were compared between the two groups.Results The total effective rate of group B was 96.23%,which was higher than 82.00%of group A,and the difference was statistically significant(χ^(2)=5.459,P=0.020);the proportion of eosinophils in group B after treatment was(11.35±2.84)%,compared with group A(16.84±3.87)%,the difference was statistically significant(t=8.241,P<0.001);after treatment in group B,sneeze,runny nose,nasal itching,nasal congestion,and physical signs scores were(1.00±0.24)points,(0.50±0.37)points,(0.50±0.41)points,(1.00±0.28)points,(0.50±0.47)points,all compared with group A(1.50±0.28)points,(1.40±0.28)points,(1.20±0.33)points,(1.60±0.35)points,(1.00±0.55)points were lower,the difference was statistically significant(t=9.748,13.858,9.511,9.634,4.969,P<0.001);the incidence of adverse reactions in group B was 3.77%,slightly lower than 8.00%of group A,the difference was not statistically significant(χ^(2)=0.244,P=0.360);the recurrence rate of group B within 1 year was 5.88%,which was lower than 31.71%of group A,and the difference was statistically significant(χ^(2)=10.551,P=0.001).Conclusion The combination of Biyuantongqiao Granules and Cetirizine is effective in treating children with allergic rhinitis.It can effectively reduce the proportion of eosinophils,improve clinical symptoms and signs,reduce the recurrence rate,and has good safety and significant efficacy.