非静脉曲张性上消化道出血的临床治疗方法及效果研究

Study on clinical treatment and effect of non-variceal upper gastrointestinal bleeding

目的分析非静脉曲张性上消化道出血利用消化内镜治疗的临床效果。方法回顾性分析120例非静脉曲张性上消化道出血患者的临床资料,依据信封法分组原则将患者分为实验组与常规组,各60例。常规组使用常规内科治疗,实验组在常规组治疗基础上使用消化内镜治疗。对比两组生命体征、临床相关指标、治疗效果及治疗前后血清炎性指标水平。结果治疗后,实验组收缩压(117.85±25.96)mm Hg(1 mm Hg=0.133 kPa)、心率(87.69±5.00)次/min、呼吸频率(18.01±4.9)次/min、休克指数(0.61±0.22)分均低于常规组的(104.42±12.06)mm Hg、(98.01±5.10)次/min、(14.75±5.30)次/min、(1.10±0.40)分,差异均具有统计学意义(P<0.05)。治疗后,实验组肠鸣音恢复时间、出血停止时间、住院时长、退热时间均短于常规组,差异均具有统计学意义(P<0.05)。实验组治疗总有效率为98.33%高于常规组的86.67%,差异具有统计学意义(P<0.05)。治疗后,实验组血清白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平均低于常规组,差异均具有统计学意义(P<0.05)。结论非静脉曲张性上消化道出血利用消化内镜治疗效果甚佳,其能减少出血复现且病理体征消减明显,临床应用价值高。

Objective To analyze the clinical effect of digestive endoscopy in the treatment of non-variceal upper gastrointestinal bleeding.Methods A total of 120 patients with non-variceal upper gastrointestinal bleeding were divided into experimental group and conventional group according to envelope method,with 60 cases in each group.The conventional group was treated with conventional medical treatment,and the experimental group was treated with digestive endoscopy based on the conventional group.The vital signs,clinical related indicators,therapeutic effect,serum inflammatory indicators before and after treatment were compared between the two groups.Results After treatment,the systolic blood pressure(117.85±25.96)mm Hg(1 mm Hg=0.133 kPa),heart rate(87.69±5.00)beats/min,respiratory rate(18.01±4.9)times/min and shock index(0.61±0.22)points of the experimental group were lower than(104.42±12.06)mm Hg,(98.01±5.10)beats/min,(14.75±5.30)times/min and(1.10±0.40)points of the conventional group,and the difference was statistically significant(P<0.05).After treatment,the recovery time of bowel sounds,bleeding stop time,hospitalization time and antipyretic time of the experimental group were shorter than those of the conventional group,and the difference was statistically significant(P<0.05).The total effective rate 98.33%of the experimental group was higher than 86.67%of the conventional group,and the difference was statistically significant(P<0.05).After treatment,the serum interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)of the experimental group were lower than those of the conventional group,and the difference was statistically significant(P<0.05).Conclusion Digestive endoscopy is effective in the treatment of non-variceal upper gastrointestinal bleeding,which can reduce the recurrence of bleeding,reduce the pathological signs obviously and has high clinical application value.