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补体因子H与精神分裂症快感缺失的关系研究 被引量:1

Correlation between complement factor H and anhedonia in schizophrenia
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摘要 目的探究精神分裂症患者快感缺失与补体因子H(CFH)的关系。方法选取100例首发精神分裂症患者作为病例组,另选取111例健康志愿者作为对照组。使用阳性与阴性症状量表(PANSS)和时间性快感体验量表(TEPS)分别评估患者精神症状和快感缺失,使用酶联免疫吸附测定法(ELISA)法检测患者的血清CFH水平。比较两组临床资料,分析血清CFH水平与临床特征的相关性,并进行精神分裂症患者TEPS总分相关因素的多元线性回归分析。结果两组的性别、年龄比较差异无统计学意义(P>0.05)。病例组的TEPS总分、期待性快感缺失评分和消费性快感缺失评分均显著低于对照组,差异具有统计学意义(P<0.05)。病例组的血清CFH水平显著低于对照组,差异具有统计学意义(P<0.05)。相关性分析显示,病例组血清CFH水平与PANSS阴性症状评分和总分呈显著性负相关(r=-0.29、-0.21,P=0.01、0.05<0.05),与TEPS总分呈显著性正相关(r=0.23, P=0.03<0.05);对照组血清CFH水平与TEPS总分、期待性快感缺失评分和消费性快感缺失评分均无相关性(P>0.05)。TEPS总分与PANSS阴性症状评分呈负相关(t=-3.33, P=0.001<0.05),与血清CFH水平呈正相关(t=2.49, P=0.015<0.05)。结论 CFH水平与精神分裂症患者快感缺失的严重程度有关,提示该蛋白可能参与了快感缺失的发生过程。 Objective To investigate the correlation between anhedonia and complement factor H(CFH)in schizophrenia patients.Methods There were 100 patients with first-onset schizophrenia selected as the case group,and 111 healthy volunteers as the control group.The positive and negative symptom scale(PANSS)and the temporal experience of pleasure scale(TEPS)were used to evaluate the patients’psychiatric symptoms and anhedonia,respectively,and the enzyme-linked immunosorbent assay(ELISA)was used to detect the serum CFH level of the patients.The clinical data of the two groups was compared.The correlation between serum CFH level and clinical characteristics was analyzed,and the multiple linear regression analysis of related factors of total TEPS scores in schizophrenia patients was carried out.Results There was no statistically significant difference in gender and age between the two groups(P>0.05).The total TEPS score,expected anhedonia score and consumer anhedonia score of the case group were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).The serum CFH of the case group was significantly lower than those of the control group,and the difference was statistically significant(P<0.05).In the case group,correlation analysis showed that the serum CFH was negatively correlated with PANSS score and total score(r=-0.29,-0.21;P=0.01,0.05<0.05),and was significantly correlated with total TEPS score(r=0.23,P=0.03<0.05).In the control group,the serum CFH was not correlated with total TEPS score,expected anhedonia score and consumer anhedonia score(P>0.05);the total TEPS score was negatively correlated with PANSS score(t=-3.33,P=0.001<0.05),and positively correlated with serum CFH(t=2.49,P=0.015<0.05).Conclusion The level of CFH is related to the severity of anhedonia in patients with schizophrenia,suggesting that CFH may be involved in the occurrence of loss of pleasure.
作者 范建华 张程赪 许明胜 卢涛 张毅 张晨 FAN Jian-hua;ZHANG Cheng-cheng;XU Ming-sheng(Department of Psychiatry,Third People’s Hospital of North Guangdong,Shaoguan 512200,China)
出处 《中国实用医药》 2021年第13期84-87,共4页 China Practical Medicine
基金 韶关市科技计划项目(200813154531876)项目名称:补体因子H在精神分裂症快感缺失中的作用机制。
关键词 精神分裂症 阴性症状 快感缺失 补体因子H Schizophrenia Negative symptoms Anhedonia Complement factor H
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