门冬胰岛素30联合二甲双胍治疗老年初诊2型糖尿病的疗效观察

Efficacy observation of insulin aspart 30 combined with metformin in the treatment of newly diagnosed type 2 diabetes in the elderly

目的探究门冬胰岛素30联合二甲双胍治疗老年初诊2型糖尿病(T2DM)的疗效。方法 94例老年初诊T2DM患者,随机分为单一组及联合组,各47例。单一组采用门冬胰岛素30治疗,联合组采用二甲双胍+门冬胰岛素30治疗。比较两组患者治疗前后的空腹血糖(FBG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(2 h PG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平,血糖控制效果。结果治疗后,联合组患者的FBG、HbA1c、2 h PG水平分别为(5.84±0.72)mmol/L、(6.23±1.04)%、(8.30±0.61)mmol/L,均低于单一组的(6.51±1.37)mmol/L、(7.92±1.05)%、(11.03±1.24)mmol/L,差异具有统计学意义(P<0.05)。治疗后,联合组患者的TG、TC、LDL-C水平低于单一组, HDL-C水平高于单一组,差异具有统计学意义(P<0.05)。联合组患者的血糖控制率为95.74%,高于单一组的80.85%,差异具有统计学意义(P<0.05)。结论在老年初诊T2DM治疗中,应用门冬胰岛素30联合二甲双胍,能有效控制患者血糖,值得进一步推广研究。

Objective To investigate the efficacy of insulin aspart 30 combined with metformin in the treatment of newly diagnosed type 2 diabetes(T2DM)in the elderly.Methods A total of 94 elderly patients with newly diagnosed T2DM were randomly divided into single group and combined group,with 47 cases in each group.Single group was treated with insulin aspart 30,and combined group was treated with metformin and insulin aspart 30.The fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),2-h postprandial glucose(2 h PG),triglycerides(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)levels,and blood sugar control effect were compared between the two groups.Results After treatment,the levels of FBG,HbA1c and 2 h PG of combined group were(5.84±0.72)mmol/L,(6.23±1.04)%and(8.30±0.61)mmol/L of combined group were lower than(6.51±1.37)mmol/L,(7.92±1.05)%and(11.03±1.24)mmol/L of single group,and the difference was statistically significant(P<0.05).After treatment,the levels of TG,TC and LDL-C of combined group were lower than those of single group,and HDL-C level was higher than that of single group,and the difference was statistically significant(P<0.05).The blood sugar control rate of combined group was 95.74%,which was higher than 80.85%of single group,and the difference was statistically significant(P<0.05).Conclusion Combination of insulin aspart 30 and metformin can effectively control the blood sugar of elderly patients with newly diagnosed T2DM,and is worthy of further promotion and research.