儿童肝母细胞瘤预后相关因素的研究进展

Research progress on prognostic factors of hepatoblastoma in children

肝母细胞瘤(hepatoblastoma,HB)是儿童最常见的肝脏原发性恶性肿瘤,虽然高危患者的治疗结局仍不理想,但近年来其整体预后已得到了极大改善,目前已使用化疗、手术切除程度、PRETEXT分期、病理分型、年龄、种族、基因等指标对HB患者的预后进行评估,但仍有较多因素的预后价值尚未明确。近年来国内外学者在研究HB预后相关因素方面取得了一些新的研究成果,使得HB的远期疗效评估成为可能。本文针对儿童肝母细胞瘤预后相关因素的研究进展进行综述。

Hepatoblastoma(HB)is the most common primary malignant tumor of the liver in children.Its prognosis has been greatly improved in recent years,but the treatment outcome of high-risk patients is still not ideal.At present,the prognosis of HB has been evaluated using chemotherapy,degree of surgical resection,PRETEXT staging,pathological classification,age,race,gene and other indicators,but the prognostic value of many factors is still unclear.In recent years,domestic and foreign scholars have made some new research results in the study of HB-related prognostic factors,making it possible to evaluate the long-term efficacy of HB.This article will review the research progress on prognostic factors of childhood hepatoblastoma.