长链非编码RNA对股骨头缺血性坏死发病的机制参与和调控

Participation and regulation of long-chain non-coding RNA on pathogenesis of avascular necrosis of the femoral head

背景:股骨头缺血坏死的发病率较高,好发于中青年,大部分患者在就诊时骨坏死已进展至中晚期,关节置换可能是疗效最好的治疗方式。但人工假体有一定的使用寿命,如果年轻患者接受了关节置换,则后期可能需要经历一次或多次翻修。早期诊断、采用简单的方法阻断骨坏死进展、避免股骨头塌陷是股骨头缺血性坏死诊疗的目标。所以,探索其发病机制,寻找新的有效的非手术治疗方法将具有很重要的现实意义。目的:探索长链非编码RNA调控股骨头缺血性坏死作用和发病机制的,为股骨头缺血性坏死的治疗提供新的思路和方法。方法:计算机检索Pub Med数据库2011至2021年相关文献,应用摘要检索进行检索,并进行系统的归纳、总结和分析,对长链非编码RNA调控股骨头缺血性坏死的作用及发病机制的研究新进展进行系统的总结和阐述。结果与结论:最终纳入文献47篇。(1)股骨头缺血性坏死的发病机制目前有许多理论,这些理论都与长链非编码RNA有或多或少的联系;目前股骨头缺血性坏死的发病机制主流的观念与骨髓间充质干细胞、骨微血管内皮细胞凋亡、异常分化,以及脂肪代谢紊乱血液供应不足、基因多态性相关;(2)长链非编码RNA在股骨头缺血性坏死发病机制中的作用,目前还有很多问题亟待解决,如与股骨头缺血性坏死发病相关的长链非编码RNA目前尚不十分清楚,股骨头缺血性坏死的骨微血管内皮细胞中的长链非编码RNA对凋亡的作用机制和股骨头缺血性坏死中的基因多态性如何调控长链非编码RNA等问题;(3)因此,对长链非编码RNA在股骨头缺血性坏死发病机制中作用的研究有助于为股骨头坏死的临床治疗提供新思路和新方法。

BACKGROUND:The incidence of avascular necrosis of the femoral head is high,and it usually occurs in young and middle-aged people.Most of the patients with osteonecrosis have progressed to the middle and late stage when they come to see a doctor,and joint replacement may be the most effective treatment.However,the prosthesis has a certain service life,and if young patients undergo joint replacement,they may need to undergo one or more revision at a later stage.Early diagnosis,using simple methods to block the progression of osteonecrosis and avoiding the collapse of the femoral head are the goals of diagnosis and treatment of avascular necrosis of the femoral head.Therefore,it is of great practical significance to explore its pathogenesis and find new effective nonoperative treatment.OBJECTIVE:To explore the effect and pathogenesis of long-chain non-coding RNA on avascular necrosis of the femoral head,and to provide new ideas and methods for the treatment of avascular necrosis of the femoral head.METHODS:The computer was used to search the relevant articles in PubMed database from 2011 to 2021.Abstract retrieval was used to search.Finally,articles were systematically summarized and analyzed.The role of long-chain non-coding RNA in regulating avascular necrosis of the femoral head and the new progress in the pathogenesis of avascular necrosis of the femoral head were systematically summarized and expounded.RESULTS AND CONCLUSION:A total of 47 articles were finally included.(1)There are many theories about the pathogenesis of avascular necrosis of the femoral head,all of which are more or less related to long-chain non-coding RNA.At present,the mainstream concept is related to bone marrow mesenchymal stem cells,brain microvascular endothelial cells apoptosis,abnormal differentiation,fat metabolism disorder,insufficient blood supply and gene polymorphism.(2)Regarding the role of long-chain non-coding RNA in the pathogenesis of avascular necrosis of the femoral head,there are still many problems to be solved.For example,the pathogenesis of avascular necrosis of the femoral head associated with long-chain non-coding RNA is still not very clear,the mechanism of long-chain non-coding RNA in bone microvascular endothelial cells of avascular necrosis of the femoral head on apoptosis and how the gene polymorphism in avascular necrosis of the femoral head regulates long-chain non-coding RNA.(3)Therefore,the study on the role of long-chain non-coding RNA in the pathogenesis of avascular necrosis of the femoral head is helpful to provide new ideas and methods for the clinical treatment of avascular necrosis of the femoral head.