不同红细胞输注量对早产儿贫血的治疗效果

Analysis of the effects on different erythrocyte infusion amount in the treatment of premature anemia

目的探讨不同红细胞输注(RBCT)量对早产儿贫血的治疗效果。方法收集264例贫血早产儿RBCT的临床资料,根据每次RBCT量分为标准输血量组[SBT组10~15 mL/(kg·次)]和高输血量[HBT组15.1~20 mL/(kg·次)],记录2组患儿的一般情况(胎龄、出生体质量、性别、分娩方式、胎次、Apgar评分)、住院情况[机械通气时间、胃肠外营养时间、吸氧时间、住院时间、累计RBCT量,累计RBCT次数、血红蛋白(Hb)及红细胞压积(Hct)的升高幅度]及住院期间并发症[肝功能损伤、肾功能损伤、红细胞增多症及支气管肺发育不良(BPD)、脑室内出血(IVH)、新生儿坏死性小肠结肠炎(NEC)、院内感染(NI)、早产儿视网膜病变(ROP)]的发生率,比较不同RBCT量对患儿的治疗效果。结果两组患儿一般情况比较差异无统计学意义(P>0.05),SBT组患儿机械通气时间、胃肠外营养时间、住院时间较HBT组短(P<0.05),SBT组累计RBCT量、Hb及Hct升高幅度低于HBT组(P<0.05),2组患儿在吸氧时间、累计RBCT次数及住院期间并发症发病率比较差异无统计学意义(P>0.05)。结论SBT可减少贫血早产患儿住院治疗期间的机械通气时间、胃肠外营养时间、住院时间及住院期间RBTC总量,治疗效果优于HBT。

Objective To investigate the effects on different amount of red blood cell transfusion(RBCT)treatment of premature anemia and provide reasonable basis.Methods Clinical data of 264 cases of preterm anemia with RBCT were collected and divided into into standard blood transfusion volume groups[10-15 mL/(kg·time)]and high blood transfusion volume[15.1-20 mL/(kg·time)]according to each RBCT volume The general situation(gestational age,birth weight,gender,delivery mode,number of births,Apgar score),hospitalization(mechanical ventilation time,parenteral nutrition time,oxygen intake time,hospitalization time,cumulative RBCT volume,cumulative RBCT number,Hb and HCT increase rate)and the incidence of complications during hospitalization of the two groups were recorded and analyzed respectively.The therapeutic effects of different RBCT amounts on the children were compared.Results There was no significant difference in general conditions between the two groups(P>0.05).The duration of mechanical ventilation,parenteral nutrition and hospitalization in the SBT group were shorter than those in the HBT group(P<0.05).The increase rates of cumulative RBCT,Hb,and Hct in SBT group were lower than those in HBT group(P<0.05).There were no significant differences in the duration of oxygen inhalation,the cumulative number of RBCT and the incidence of complications during hospitalization between the two groups(P>0.05).Conclusion SBT can reduce the duration of mechanical ventilation and parenteral nutrition,and reduce the length of hospital stay and the total amount of RBTC during hospitalization.SBT is better than HBT in the treatment of premature anemia.