人精子鱼精蛋白与畸形精子的相关性

Protamine and Teratozoospermia:A Short Review

畸形精子症为男性不育症的常见类型,人类精子中的鱼精蛋白作为精子变形期与成熟期的重要蛋白,与精子形态密切相关。对近年来人精子鱼精蛋白与畸形精子症相关文献进行综述,发现在人精子中鱼精蛋白缺陷、鱼精蛋白基因表达异常及鱼精蛋白的基因多态性时,均可出现精子形态异常,降低患者生育力;在畸形精子症患者的精子中可出现鱼精蛋白缺陷、鱼精蛋白基因表达异常及鱼精蛋白的基因多态性;提示人精子鱼精蛋白异常是畸形精子症的重要影响因素。研究者尝试对鱼精蛋白异常的畸形精子症患者进行针对性治疗研究,取得了一定疗效。

Teratozoospermia is a common type of male infertility.Protamine in human sperm,as an important protein in sperm transformation and maturity phases,is closely related to sperm morphology.The literature on protamine and teratozoospermia was reviewed.It was found that the defect in protamine molecule,the abnormal expression of protamine,and the polymorphisms of protamine gene,could all lead to abnormal morphology of human sperm and reduce the fertility of patients.Interestingly,the inverted correlation is also tenable.It was suggested that abnormal protamine in human sperm was an important factor of teratozoospermia.The definitive therapy was tried in those patients with the teratozoospermia related to abnormal protamine.