2017~2019年某院住院患者抗菌药物使用情况分析

Analysis on use of antibacterial drugs in the inpatients in our hospital from 2017 to 2019

目的分析2017~2019年某院住院抗菌药物的使用情况,为抗菌药物的下一步管理提供思路。方法调取2017~2019年住院抗菌药物的相关用药数据,对用药频度(DDDs)、使用强度(AUD)进行统计分析。结果2017~2019年使用频度最高的4类抗菌药物分别为头孢菌素类、青霉素类、硝基咪唑类和喹诺酮类。近3年AUD水平连续下降,2019年AUD为65.96 DDDs/(100人·天),离全国平均水平仍有一定的距离。抗菌药物给药途径以静脉注射为主,非限制级抗菌药物的DDDs、AUD最高,但DDDs逐年降低,限制级、特殊级选择性逐年升高。2017~2019年DDDs排名前2位的抗菌药物为注射用美洛西林钠、注射用头孢呋辛钠,美洛西林的选择性降低,头孢地嗪的选择性增加。结论2017~2019年某院住院抗菌药物AUD连续下降,说明抗菌药物管理有效,但需关注抗菌药物选择过于集中、第3代头孢菌素广泛使用的问题。

Objective To analyze the use of antibacterial drugs in the inpatients of our hospital from 2017 to 2019,and to provide ideas for the later management.Methods The data of antibacterial drugs used in the inpatients from 2017 to 2019 were collected,and DDDs and AUD were analyzed statistically.Results Top 4 types antibacterial drugs in the list of DDDs were cephalosporins,penicillins,nitroimidazoles and quinolones.The AUD level had declined continuously.In 2019,the AUD was 65.96 DDDs/(100 people·day),which was still a certain distance from the national average level.Intravenous drugs were the most choice.The DDDs and AUD of unrestricted antibacterial drugs were the highest,but its DDDs decreased year by year,and the DDDs of restricted and special antibacterial drugs increased year by year.During 2017~2019,mezlocillin sodium for injection and cefuroxime sodium for injection ranked in the first two places in terms of DDDs.The selectivity of mezlocillin decreased and that of cefodizime increased.Conclusion The AUD in the inpatients of our hospital had decreased continuously from 2017 to 2019,suggesting that the management of antibacterial drugs was effective.But problems that the selection of antibacterial drugs was too concentrated and the third-generation cephalosporins were widely used should be concerned.