药用辅料影响诊疗安全研究进展

Advances in Research on Impact of Drug Excipients on Safety of Diagnosis and Treatment

目的提高对药物制剂中药用辅料影响诊疗安全的认识,为进一步安全合理用药提供参考。方法对近年来药用辅料生理活性、理化性质等影响诊疗过程的文献进行综述。结果药用辅料自身的固有性质在临床上常常与其他医疗因素共同作用于人体,对疾病转归和医务人员的判断产生不容忽视的影响。药用辅料导致的不良反应,也常常与其自身固有的性质有关。结论辅料作为药品必不可少的部分,其在诊疗过程中的地位和作用与临床用药安全关系密切。为规避用药风险,药品辅料与主药应得到同样的重视。

Objective To find out more about the influence of drug excipients in preparations on the safety of diagnosis and treatment and to provide reference for safe and rational use of drugs. Methods Recent literature related to the physiological activity, physical and chemical properties of drug excipients that affected the diagnosis and treatment process was reviewed. Results The inherent properties of drug excipients often acted on the human body clinically in conjunction with other factors of health care, which could adversely impact the outcome of a disease and the judgment of health care providers. Adverse drug reactions(ADR) caused by drug excipients were often related to their inherent properties. Conclusion As essential ingredients of preparations, drug excipients could make difference to the safety of clinical medication in the process of diagnosis and treatment. Drug excipients deserve the same amount of attention as the main active ingredients of preparations in order to minimize medication risks.