中药穴位敷贴联合康艾注射液预防恶性肿瘤患者铂类联合化疗不良反应的临床观察

Clinical Observation on Acupoint Application of Traditional Chinese Medicine Combined with Kangai Injection to Prevent the Adverse Reactions of Platinum and Chemotherapy in Cancer Patients

目的观察中药穴位敷贴联合康艾注射液预防铂类联合化疗不良反应的疗效。方法选取2015年1月—2020年6月收治的200例恶性肿瘤患者,按随机数字表法分为基础组、对照1组、对照2组和试验组,每组50例,基础组给予铂类联合化疗方案治疗,化疗前给予常规护肝、止吐等对症处理,对照1组在基础组治疗基础上联合中药穴位敷贴治疗,对照2组在基础组治疗基础上加用康艾注射液治疗,试验组加用中药(安中降逆贴、三味泄浊贴)穴位敷贴联合康艾注射液治疗。比较各组患者治疗不良反应发生情况,评估治疗前后生活质量评分(KPS)及肝肾功能变化。结果试验组患者恶心呕吐分级低于对照1组、对照2组与基础组(P <0.05);试验组化疗中期、化疗完成2 d便秘症状评分低于对照1组、对照2组与基础组(P <0.05);化疗完成2 d后试验组白细胞计数(WBC)、中性粒细胞计数(NE)高于对照1组、对照2组与基础组(P <0.05);化疗完成2 d后试验组谷丙酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血清总胆红素(TBIL)、尿素氮(BUN)、血肌酐(Scr)低于对照1组、对照2组与基础组(P <0.05);试验组化疗完成2 d后KPS评分高于对照1组、对照2组与基础组(P <0.05)。结论运用中药穴位敷贴联合康艾注射液能有效减轻恶性肿瘤患者铂类联合化疗时不良反应,较单独联合康艾注射液或中药穴位敷贴更能改善患者便秘症状,保护肝肾功能,提高患者生活质量。

Objective To observe the efficacy of acupoint application of traditional Chinese medicine combined with Kangai injection in preventing adverse reactions of platinum combined with chemotherapy. Methods A total of 200 patients with malignant tumors admitted from January 2015 to June 2020 were selected and divided into basis group,control group1,control group 2 and the test group according to the random number table method,with 50 cases in each group. The basic group was given platinum Combined chemotherapy regimen treatment,routine treatments such as liver protection and antiemetic treatment were given before chemotherapy. The control group 1 was treated with traditional Chinese medicine acupoint application on the basis of the basic group,and the control group 2 was treated with Kangai injection on the basis of the basic group treatment. The experimental group Plus Chinese medicine( Anzhong Jiangni Paste,Sanwei Xiezhuo Paste) acupoint application combined with Kangai injection. The occurrence of adverse reactions in each group of patients was compared,and the changes in quality of life score( KPS) and liver and kidney function before and after treatment were evaluated. Results The nausea and vomiting grades of the test group were lower than those of the control group 1,control group 2 and the basic group( P < 0. 05);the test group’s constipation symptom scores were lower than those of the control group 1,control group 2 and the basic group( P < 0. 05);The white blood cell count( WBC) and neutrophil count( NE) of the test group were higher than the control group 1,the control group 2 and the basic group 2 days after the completion of chemotherapy( P < 0. 05);the test was conducted 2 days after the completion of chemotherapy Group glutamate aminotransferase( ALT),aspartate aminotransferase( AST),serum total bilirubin( TBIL),urea nitrogen( BUN),and blood creatinine( Scr) were lower than control group 1,control group 2. The KPS score of the experimental group was higher than the control group 1,the control group 2 and the basic group( P < 0. 05). Conclusion The use of traditional Chinese medicine acupoint application combined with Kangai injection can effectively alleviate the adverse reactions of patients with malignant tumors. Compared with using Kangai Injection or traditional Chinese medicine acupoint application,it can improve the symptoms of constipation,protect liver and kidney function,and improve the quality of life of patients.