粪便钙卫蛋白联合血液指标在诊断及评估溃疡性结肠炎活动度中的临床价值

Clinical value of fecal calprotectin combined with blood indicators in diagnosis and evaluation of activity of ulcerative colitis

目的探讨粪便钙卫蛋白(fecal calprotectin,FC)联合血液指标在诊断及评估溃疡性结肠炎断为UC的100例患者进行回顾性分析,并选择同期在我院诊断为功能性胃肠病的100例患者作为对照组,分别检测FC含量,比较两组FC。再根据UCEIS将100例UC患者分为缓解组、镜下活动轻度组、镜下活动中度组、镜下活动重度组,分别检测各组血液指标(CRP、ESR、WBC、NLR、Hb、Alb)。比较不同UC效能。结果 UC患者FC浓度明显高于对照组,活动期各组UC患者FC水平亦高于对照组(P <0.05)。FC分别联合血液指标作ROC曲线,发现单FC在评估UC是否活动中已具有较高的诊断价值,同时FC联合血液指标评估价值更优于FC单一指标。结论 FC是一种判断UC患者病情活动程度的较好评估指标,其可作为临床上对UC患者进行病情活动评估的辅助指标。

Objective Investigate the clinical value of fecal calprotectin(FC)combined with blood indicators in the diagnosis and evaluation of the activity of ulcerative colitis(UC).Methods 100 patients with UC diagnosed in Jiangsu Province Hospital from December 2017 to October 2020 were retrospectively analyzed,and 100 patients diagnosed with functional gastrointestinal disease in our hospital during the same period were selected as the control group,FC content was detected and compared between the two groups.According to the Ulcerative Colitis Endoscopic Severity Index(UCEIS),100 ulcerative colitis patients were divided into remission group,mild endoscopic activity group,moderate endoscopic activity group and severe endoscopic activity group,blood⁃related indicators(CRP,ESR,WBC,NLR,Hb,ALB)were detected respectively.FC and blood⁃related indicators of patients with different UC groups were compared.The ROC curve was drawn to analyze the diagnostic efficacy of FC combined with blood⁃related indicators to determine whether the UC endoscopy is active.Results The FC concentration of UC patients was significantly higher than that of the control group.The FC level of UC patients in the active phase was also higher than that of the control group(P<0.05).FC was combined with blood⁃related indicators to make ROC curve,single FC had a high diagnostic value,and the evaluation value of FC com⁃bined with blood indicators was better than FC single index.Conclusion FC is a good evaluation index to judge the disease activity of UC patients,and it can be used as an auxiliary index to evaluate the disease activity of UC patients.