mTOR信号通路在糖尿病肾病发病机制中的研究进展

Research Progress of mTOR Pathway in Pathogenesis of Diabetic Nephropathy

糖尿病肾病(diabetic nephropathy,DN)是糖尿病最常见的并发症之一,因其具有高发病率且与晚期肾病、心血管疾病和过早死亡等风险相关,糖尿病肾病已成为全球性的公共健康问题,但目前其发病机制尚不清楚。雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)是一种丝氨酸/苏氨酸的蛋白酶,在延迟细胞凋亡以及促进细胞分裂、细胞存活、血管生成中发挥着重要作用。近年来有研究表明,mTOR存在于DN进展的关键步骤中,包括自噬、炎症及氧化应激等。因此,就mTOR介导的自噬、炎症及氧化应激信号通路在DN发病机制中的相关研究进展做一综述,以期为DN治疗及预防提供理论参考。

Diabetic nephropathy(DN)is one of the most common complications of diabetes.Because of its high incidence and related to the risks of advanced kidney disease,cardiovascular disease and premature death,DN has become a global public health problem,but its pathogenesis is still unclear.Mammalian target of rapamycin(mTOR)is a serine/threonine protease,which plays an important role in delaying apoptosis and promoting cell division,cell survival and angiogenesis.Recent studies have shown that mTOR exists in the key steps of DN progression,including autophagy,inflammation and oxidative stress.Therefore,the research progress of mTOR-mediated autophagy,inflammation and oxidative stress signaling pathways in the pathogenesis of DN was reviewed,in order to provide theoretical reference for the treatment and prevention of DN.