腹腔镜手术联合戈舍瑞林皮下注射治疗中重度子宫内膜异位症的临床研究

Clinical Study of Laparoscopy Combined with Subcutaneous Injection of Goserelin in the Treatment of Moderate and Severe Endometriosis

目的:探讨腹腔镜手术联合戈舍瑞林皮下注射治疗中重度子宫内膜异位症患者的临床疗效及安全性。方法:选取2018年1月—2020年6月期间在无锡市人民医院接受治疗的中重度子宫内膜异位症患者60例,随机分为观察组和对照组,每组各30例;对照组给予腹腔镜手术治疗处理,观察组在对照组的基础上联合使用戈舍瑞林皮下注射治疗,对比两组疗效、性激素水平及预后。结果:治疗后观察组患者复发率(3.33%)低于对照组;妊娠率(53.33%)、症状缓解率(93.33%)较高于对照组,差异均有统计学意义(P<0.05);治疗后两组患者促卵泡生成素(FSH)、黄体生成素(LH)、雌激素(E2)以及血清CA125均有不同程度的改善,但治疗后观察组激素水平指标FSH(5.58±1.39)、E2(59.22±8.58)、LH(2.33±0.31)明显低于对照组,差异均有统计学意义(P<0.05);治疗后观察组血清CA125(25.21±5.22)明显低于对照组,差异有统计学意义(P<0.05)。结论:腹腔镜手术联合戈舍瑞林皮下注射治疗中重度子宫内膜异位症,能降低患者复发率以及血清CA125水平,改善患者体内激素分泌状况,能有效缓解患者临床症状,值得临床推广应用。

Objective:To investigate the clinical efficacy and safety of laparoscopic surgery combined with subcutaneous injection of goserelin in the treatment of moderate to severe endometriosis.Methods:From January 2018 to June 2020,60 patients with moderate and severe endometriosis in the hospital were selected and randomly divided into observation group and control group,30 in each group.The control group was treated with laparoscopic surgery,and the observation group was treated with subcutaneous injection of goserelin on the basis of the control group,and the efficacy and sex hormone water of the two groups were compared.Results:After treatment,the recurrence rate(3.33%)in the observation group was lower than that in the control group,the pregnancy rate(53.33%)and symptom remission rate(93.33%)in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,follicle stimulating hormone(FSH),luteinizing hormone(LH),estrogen(E2)and serum CA125 in the two groups improved to varying degrees.However,after treatment,the hormone levels FSH(5.58±1.39),E2(59.22±8.58),and LH(2.33±0.31)of the observation group were significantly lower than those of the control group,and the differences were statistically significant(P<0.05).After treatment,serum CA125(25.21±5.22)in the observation group was significantly lower than that in the control group(P<0.05).Conclusion:Laparoscopic surgery combined with subcutaneous injection of goserelin in the treatment of moderate and severe endometriosis can reduce the incidence of endometriosis.The recurrence rate and serum CA125 level can improve the hormone secretion in patients and effectively alleviate the clinical symptoms of patients,which is worthy of clinical application.