参麦注射液联合左卡尼汀对缺血性心肌病心力衰竭患者心功能及心肌微循环的影响

Effect of Shenmai injection combined with levocarnitine on cardiac function and myocardial microcirculation in patients with ischemic cardiomyopathy and heart failure

目的观察参麦注射液联合左卡尼汀对缺血性心肌病心力衰竭患者心功能及心肌微循环的影响。方法选取我院2017年3月至2020年1月收治的80例缺血性心肌病心力衰竭患者,将其随机分为对照组和观察组,各40例。对照组采用左卡尼汀治疗,观察组在对照组基础上加用参麦注射液治疗。比较两组的临床疗效、心功能指标、心肌微循环指标及生活质量评分。结果观察组的治疗总有效率显著高于对照组(P<0.05)。治疗后,两组的CI、SI及EF均显著升高,缺血持续时间均显著缩短,缺血总负荷、总缺血频度、最大ST段移位及MLHF-Q评分均显著降低,且观察组优于对照组(P<0.05)。结论参麦注射液联合左卡尼汀治疗缺血性心肌病心力衰竭能够有效改善患者的心功能和心肌微循环,提高临床治疗效果和患者的生活质量。

Objective To observe the effect of Shenmai injection combined with levocarnitine on cardiac function and myocardial microcirculation in patients with ischemic cardiomyopathy and heart failure.Methods Eighty patients with ischemic cardiomyopathy and heart failure admitted in our hospital from March 2017 to January 2020 were randomly divided into control group and observation group,with 40 cases in each group.The control group was treated with levocarnitine,and the observation group was treated with Shenmai injection on the basis of the control group.The clinical efficacy,cardiac function indexes,myocardial microcirculation indexes and quality of life score were compared between the two groups.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,CI,SI and EF in the two groups significantly increased,ischemic duration significantly shortened,and total ischemic load,total ischemic frequency,maximum ST segment shift and MLHF-Q score significantly decreased,and those in the observation group were better than the control group(P<0.05).Conclusion Shenmai injection combined with levocarnitine in the treatment of ischemic cardiomyopathy and heart failure can effectively improve the cardiac function and myocardial microcirculation of patients,elevate the clinical treatment effect and the quality of life of patients.