纳米材料在肿瘤微波诊疗中的研究进展

Advances in nanomaterials for microwave-induced diagnosis and therapy of tumor

近年来,随着纳米医学的飞速发展,纳米材料在生物医学领域,尤其是在肿瘤的诊断和治疗方面引起了科学家们越来越多的关注。纳米材料作为融合了多模态造影和药物递送等性能的多功能纳米平台,有望通过介导多模态分子影像实现早期肿瘤精确诊断,同时通过联合化疗、热疗等手段实现肿瘤的高效综合治疗。目前已开发一系列具有响应微波产生超声波、热量、活性氧自由基等性能的多功能纳米材料,其不仅可作为磁共振成像(MRI)成像、微波热声成像等成像造影剂,还可通过介导热声治疗、热疗和微波动力治疗等治疗手段精准杀灭肿瘤。文章对响应微波的纳米材料类型及其在肿瘤诊疗方面的研究进展进行了简要概述。

In recent years,with the rapid development of nanomedicine,the tumor diagnosis and therapy dependent on multifunctional nanomaterials have received great attention.Nanomaterials as integrated multimodal imaging and drug delivery performance of multifunctional nano platforms are expected to achieve accurate diagnosis of early tumors by mediating multimodal molecular images.A series of multifunctional nanomaterials with the properties of generating ultrasonic,heat and reactive oxygen species(ROS)under microwave excitation have been developed.These can not only be used as imaging contrast agent such as MRI imaging and microwave thermoacoustic imaging,but also kill tumors accurately by mediating thermoacoustic therapy,thermotherapy and microwave dynamic therapy.This paper briefly summarized the types of microwave-absorbing nanomaterials and their research progress in tumor diagnosis and treatment.