胶质瘤组织CFL1表达水平与胶质瘤病人术后放疗效果的关系

Relationship between expression level of CFL1 in glioma tissues and radiotherapy outcomes of patients with glioma

目的探讨胶质瘤组织丝切蛋白-1(cofilin-1,CFL1)表达水平与胶质瘤病人术后放疗效果的关系。方法选择2016年12月~2018年12月接受术后放疗治疗的脑胶质瘤64例,参照实体瘤评价标准评估放疗效果:完全缓解(CR),部分缓解(PR),疾病稳定(SD),疾病进展(PD);客观缓解率(ORR)=(CR+PR)/总例数。采用免疫组化方法检测胶质瘤组织CFL1表达水平。结果64例中,CFL1阳性表达46例,阳性表达率为71.9%;高级别胶质瘤CFL1阳性表达率(92.3%,24/26)明显高于低级别胶质瘤(57.9%,22/38;P<0.05)。64例中,CR有14例,PR有18例,SD有22例,PD有10例;ORR为50.0%(32/64)。多因素logistic回归分析显示CFL1表达阳性是胶质瘤术后放疗效果不良的独立危险因素(P<0.05)。结论胶质瘤CFL1表达水平随胶质瘤级别增高明增加,CFL1阳性表达是胶质瘤术后放疗效果不良的独立危险因素。

Objective To analyze the relationship between the expression level of cofilin-1(CFL1)in glioma tissues and the radiotherapy outcomes of patients with glioma.Methods Sixty-four patients with glioma who received postoperative radiotherapy from December 2016 to December 2018 were collected to analyze.The effect of radiotherapy was evaluated according to the evaluation criteria of solid tumors,including complete remission(CR),partial remission(PR),stable disease(SD),and disease progression(PD).The objective response rate(ORR)was the ratio of(CR+PR)to total number of patients.Immunohistochemical method was used to detect the expression level of CFL1 in glioma tissues.Results Of 64 patients with glioma,46 patients(71.88%)had positive expreesion of CFL1.The positive rate of CFL1 expression in patients with high-grade glioma(92.3%,24/26)was significantly higher than that(57.9%,22/28)in patients with low-grade glioma(P<0.05).Of 64 patients with glioma,14 patients were CR,18 PR,22 SD and 10 PD.The ORR was 50.00%.Multivariate logistic regression analysis showed that CFL1 positive expression was an independent risk factor for poor radiotherapy outcomes(P<0.05).Conclusions The expression level of CFL1 in glioma increases with the grade of glioma.Positive expression of CFL1 is an independent risk factor for the poor radiotherapy outcomes of glioma patients.