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高级别胶质瘤的治疗进展 被引量:12

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摘要 胶质瘤是成人最常见的原发性脑肿瘤,高级别胶质瘤(high-grade glioma,HGG)恶性程度高,预后不良。根据2016版WHO中枢神经系统肿瘤分类报告,HGG包括间变性星形细胞瘤(Ⅲ级)、间变性少突胶质细胞瘤(Ⅲ级)、胶质母细胞瘤(glioblastoma,GBM;Ⅳ级)和伴H3-K27M突变的弥漫性中线胶质瘤(Ⅳ级)[1]。目前,手术仍然是HGG治疗的基础,神经导航系统(neuronavigation system,NNS)和术中荧光引导等技术可帮助更好地辨识肿瘤边界和重要神经。GBM的标准术后辅助治疗是联合替莫唑胺(temozolomide,TMZ)的放、化疗,明显改善GBM的生存预后。
出处 《中国临床神经外科杂志》 2021年第5期380-384,共5页 Chinese Journal of Clinical Neurosurgery
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