重复经颅磁刺激在孤独症谱系障碍中的应用进展

Advances in application of repetitive transcranial magnetic stimulation in autism spectrum disorder

孤独症谱系障碍是一种患病率日益增长的神经发育综合征,可出现多种行为障碍。近年来,重复经颅磁刺激在孤独症谱系障碍治疗中取得了一些研究成果,但关于刺激参数选择、安全性及可行性评估方面仍存在一定争议。本文就其关于诱导长时程增强/抑制、调节皮质抑制的治疗机制、低频和高频经颅磁刺激的临床应用及目前涉及的安全性、道德伦理问题等局限性进行综述,从而为今后的研究与临床应用提供一定的参考依据。

Autism spectrum disorder is a kind of neurodevelopmental syndrome with increasing prevalence rate,and it will lead to a variety of behavioral disorders.Recently,repetitive transcranial magnetic stimulation has made some achievements in the treatment of autism spectrum disorder,but there is still some controversy about the selection of simulation parameters,safety and feasibility evaluation.Herein the treatment mechanisms for inducing long-term potentiation/inhibition and modulating cortical inhibition,the clinical applications of low-and high-frequency transcranial magnetic stimulation are reviewed,and the limitations currently involved in safety,moral and ethical issues are also discussed,thereby providing a reference basis for future research and clinical application.