关注SARS-CoV-2致病机制的研究

Unraveling the pathogenesis of severe acute respiratory syndrome coronavirus 2

严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)传染性强,可导致患者出现严重急性呼吸道感染(SARI)和多器官系统功能损害。SARS-CoV-2致病机制尚不明确,推测免疫炎症反应紊乱在其发生发展中发挥至关重要的作用。结合相关领域的研究进展,梳理SARS-CoV-2可能的致病机制,厘清未来研究方向,具有重要临床意义。

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is highly contagious and can lead to severe acute respiratory tract infection(SARI)and multiple organ dysfunction.The pathogenesis of SARS-CoV-2 is unclear.Accordingly,we speculate that dysregulated immune response plays a crucial role in the mechanisms of SARS-CoV-2 pathogenesis.It is of great clinical and reserch significance to clarify the possible pathogenesis of SARS-CoV-2.