瑞马唑仑临床应用的研究进展

Review on latest clinical practice of Remimazolam

瑞马唑仑是一种新型的超短效苯二氮䓬类药,它具有像瑞芬太尼一样器官独立的新陈代谢作用,并能像咪达唑仑一样作用于γ氨基丁酸(GABA)受体。其起效快,恢复迅速,对肝肾功能及血流动力学影响较轻,且能够被氟马西尼快速逆转,这些药理作用使瑞马唑仑在理论上成为较理想的镇静药物。本文主要就瑞马唑仑的作用机制、药代动力学、对器官功能的影响、临床应用研究进展进行综述,为其临床应用提供理论依据。

Remimazolam is a new type of ultra short acting benzodiazepine.It has an organindependent metabolism resembling remifentanil and also acts on GABA receptors.It has a fast onset of action,rapid recovery,less impact on liver and kidney function and stable hemodynamics,which pharmacological effects can be quickly reversed by flumazenil.These characteristics make remazolam an ideal sedative theoretically.This article mainly reviews progress in Remimazolam's mechanism of action,pharmacokinetics,effects on organ function and clinical application,providing theoretical basis for clinical application.