Access to Stereodefined Multifunctionalizedβ,γ-Unsaturated Ketones via Chemo,Regio-and Diastereoselective Copper-Catalyzed Diborylation of Cross-Conjugated Enynones

Main observation and conclusion Stereodefinedβ,γ-unsaturated carbony|compounds are important yet synthetically challenging units in natural products and drugs.Disclosed herein is a mild,rapid copper-catalyzed diborylation reaction of cross-conjugated enynones as a step-economic and modular approach to stereodefined multifunctionalizedβ,γ-unsaturated ketones by fine control of chemo-,regio-,Z/E and diastereoselectivity.The substrate scope was examined and a possible catalytic cycle was proposed to explain the multifaceted selectivity.