理气活血颗粒改善气滞血瘀冠心病患者足背皮肤微血管功能

Liqi Huoxue Granules Improves Microvascular Dysfunction in Coronary Heart Disease Patients with Qi Stagnation and Blood Stasis

目的:研究理气活血颗粒对气滞血瘀冠心病患者足背微血管功能的影响。方法:气滞血瘀冠心病患者31例,随机分为2组:安慰剂组(16例)和理气活血颗粒组(15例),患者每次给予安慰剂或理气活血颗粒1袋,一日2次,连续服用12周,随访12周。用激光多普勒血流仪检测患者入组期、治疗期、随访期足背微血管基础血流灌注量、局部加热至44℃时的血流灌注量、加热后比值、足部皮肤温度、足趾压力和趾/肱指数。结果:入组期,理气活血颗粒组与安慰剂组的基础血流灌注量、加热后血流灌注量、加热后比值、足部皮肤温度、足趾压力和趾/肱指数之间的比较均无显著性差异(P>0.05)。治疗期,理气活血颗粒组基础血流灌注量、加热后血流灌注量和加热后比值均有升高的趋势,其中理气活血颗粒组的加热后血流灌注量(164.86±44.82 PU)高于安慰剂组(120.62±65.24 PU),两组之间的比较差异显著(P<0.05)。随访期,理气活血颗粒组的加热后比值有增高的趋势,但是与安慰剂组比较无统计学意义(P>0.05),其它微血管功能指标无明显改变。结论:理气活血颗粒可以提高气滞血瘀冠心病患者足背皮肤血流灌注量,改善其足背皮肤微血管储备能力。

Objective:To study the effects of Liqi Huoxue granules on microvascular dysfunction in coronary heart disease patients with qi stagnation and blood stasis.Method:A total of 31 coronary heart disease patients with qi stagnation and blood stasis were enrolled and randomly assigned to receive the placebo(16 patients)or Liqi Huoxue granules(15 patients)in addition to their standard medications for the treatment of coronary heart disease.The patients were given one bag of Liqi Huoxue granules or placebotwice daily for 12 week and followed up 12 weeks.Microvascular functions including foot blood perfusion(FBP),skin temperature,toe pressure and toe/arm index were examined by Laser Doppler flowmetry during enrollment period,12 weeks of treatment and 12 weeks of follow-up.FBP was evaluated at basal skin temperature(basal FBP),after probe heating at 44℃(FBP 44℃)and the percentage of FBP 44℃/basal FBP.Results:During the enrollment period,microvascular functions had no significant difference between two groups(P>0.05).After 12 weeks of treatment,basal FBP,FBP 44℃and the percentage of FBP 44℃/basal FBP in patients in Liqi Huoxue granule group showed an increasing tendency.And treatment with Liqi Huoxue granules resulted in a significantly greater elevation in FBP 44℃than the placebo(164.86±44.82 PU vs 120.62±65.24PU,P<0.05).After 12 weeks of follow-up,although the percentage of FBP 44℃/basal FBP in patients in Liqi Huoxue granule group displayed an increase tendency,there was no significant difference between Liqi Huoxue granule group and placebo group(P>0.05).And other microvascular functions had no significant difference between two groups(P>0.05).Conclusion:Liqi Huoxue granule can increase the blood perfusion of coronary heart disease patients with qi stagnation and blood stasis,thereby improving microvascular reserve capacity and responsiveness to vasoactive substances.