尿蛋白与糖尿病微血管病变关系的研究进展

Novel Insights into the Association of Albuminuria with Microvascular Complications in Patients with Diabetes Mellitus

尿蛋白是临床上最常用的检测指标之一,研究发现它与糖尿病微血管病变密切相关。本文关注了糖代谢异常对微血管的影响,并重点论述了尿蛋白与糖尿病肾病、糖尿病视网膜病变、糖尿病神经病变等微血管病变的关系以及内在机制,证明尿蛋白可作为糖尿病相关并发症的早期预警指标和糖尿病进展的无创观测指标。

Albuminuria is a routine examination index in clinic.It has been demonstrated that albuminuria is strongly associated with diabetes mellitus microvascular complication.This paper pays attention to the role of metabolic disorder in microvessles.On this basis,we mainly focus on the association of albuminuria with microvascular complications including diabetic kidney disease,diabetic retinopathy,diabetic neuropathy and diabetic cardiovascular diseases and underlying mechanisms.Albuminruia can be used as an early warning indicator of diabetes related complications and a noninvasive observation index of diabetes progression.