红景天苷改善马拉松业余选手氧化应激损伤引起的代谢通路改变的研究

Research on the effect of salidroside on improving the metabolic pathway changes caused by oxidative stress injury in amateur marathon runners

为了探讨红景天苷对马拉松业余选手定量负荷后机体氧化应激损伤的影响,采集8名受试者服用红景天苷一个月前后安静时和定量负荷后的尿液与血液,测定血清抗氧化水平和心肌酶系活性,尿液进行代谢组学分析。发现定量负荷后较安静时受试者血清抗氧化能力失衡,心肌微损伤,尿液中筛选出缬氨酸等15种潜在生物标志物;补充红景天苷后完成相同负荷时,血清抗氧化酶活性提高,心肌损伤减轻,部分生物标志物显著回调。因此,红景天苷可能通过促进相关氨基酸和脂质代谢,增加脂肪利用,节约蛋白质,进而改善马拉松业余选手的氧化应激和心肌损伤。

In order to explore the effect of salidroside on the oxidative stress damage of amateur marathon runners after a quantitative load,the urine and blood of 8 subjects were collected at rest and after a quantitative load before and after taking salidroside for one month.The serum antioxidant level and myocardial enzyme activity were determined,and the urine was analyzed by metabonomics.Compared with the quiet state,serum antioxidant capacity of the subjects was unbalanced and myocardial microdamage was detected after quantitative loading.Fifteen potential biomarkers,including valine,were screened out from the urine.When the same load was completed after salidroside supplementation,serum antioxidant enzyme activity was increased,myocardial injury was alleviated,and some biomarkers were significantly adjusted.Thus,salidroside may improve oxidative stress and myocardial damage in marathon amateurs by promoting the metabolism of related amino acids and lipids,increasing the use of fat and saving protein.