植物内生真菌二萜活性成分的研究进展

Research progress on diterpenes from endophytic fungi

植物内生真菌中的二萜类成分结构新颖,生物活性显著。其中紫杉烷型、半日花烷型、harzianone型、异海松烷型、guanacastane型、壳梭孢菌素型、吲哚二萜型、银杏内酯型、phomactin型、cyclopiane型、norcyclostane型、松香烷型等12种骨架类型化合物具有抗肿瘤、抗病毒、抗炎、抑菌、杀虫等多种生物活性。通过整理、分析相关文献,全面综述了从植物内生真菌中所产生的137个二萜类成分及其生物活性,并对部分生物活性作用机制及构效关系加以介绍,以期为更好地开发利用植物内生真菌二萜类化合物提供参考。

The diterpenes in plant endophytic fungi have novel structure and remarkable biological activity.Among them,12 kinds of skeleton type compounds,such as taxane type,labdane type,harzianone type,isopimarane type,guanacastane type,fusoporin type,indole diterpene type,ginkgolide type,phomactin type,cyclopiane type,norcyclostane type,abietane type,have various biological activities such as anti-tumor,anti-virus,anti-inflammatory,antibacterial and insecticidal.Through sorting out and analyzing relevant literature,a comprehensive review of 137 diterpenoids and their biological activities produced from plant endophytic fungi,and an introduction to some of the biological activity mechanisms and structure-activity relationships,in order to provide a reference for the better development and utilization of plant endophytic fungi diterpenoids.