聚多卡醇注射治疗化脓性肉芽肿的效果与安全性评价

Treatment of pyogenic granuloma with polidocanol:evaluation of efficacy and safety

目的探讨1%聚多卡醇局部注射治疗化脓性肉芽肿的临床效果。方法2018年1月至2019年1月,温州医科大学附属浙江省台州医院门诊治疗化脓性肉芽肿患者32例,男14例,女18例,年龄1~61岁,均采用1%聚多卡醇局部注射治疗,回顾性分析总结治疗效果及安全性。疗效评价分为治愈、好转和无效,瘢痕评价分级为0、+、++和+++级。结果32例患者中,23例1次注射1%聚多卡醇后病灶消失;5例2次注射后病灶消失;4例注射治疗后病灶直径小于2 mm,后改用595 nm脉冲染料激光治疗1次,病灶消退。注射治疗总治愈率87.5%(28/32),有效率为100%(32/32),仅3例发生"+"级瘢痕。所有病例均无严重并发症发生,治愈后随访12个月无复发。结论1%聚多卡醇局部注射治疗化脓性肉芽肿,疗效确切、并发症少、操作方便,适合在各级医院开展。

Objective To evaluate the efficacy and safety of polidocanol in the treatment of pyogenic granuloma.Methods The clinical data of 32 patients treated by polidocanol were retrospectively analyzed from January 2018 to January 2019.The curative effect was classified as cure,improvement and ineffectiveness.According to the scar condition,they were classified as 0,+,++,and +++.Results In this study,32 patients with pyogenic granuloma were treated by polidocanol.The lesions disappeared after one injection in 23 patients and two injections in 5 patients.In 4 cases,the diameter of the lesion was reduced to less than 2 mm after one injection,and then the lesions disappeared after 1 time of 595 nm pulsed fuel laser treatment.The cure rate and effective rate of injection therapy were 87.5%(28/32)and 100%(32/32),respectively.Only 3 cases of scar were rated as+.No side effect was observed.There was no recurrence in 12 months follow-up.Conclusions The method of polidocanol local injection in pyogenic granuloma is an effective and safe treatment,and it is worth popularizing and applying.