血清单核细胞趋化蛋白-1在间质性肺疾病诊断中的价值

Value of serum monocyte chemoattractant protein-1 in the diagnosis of interstitial lung disease

目的:探讨血清单核细胞趋化蛋白-1(MCP-1)在间质性肺疾病(ILD)诊断中的临床价值。方法:随机选取80例ILD患者为病例组,同期80例非吸烟的健康体检者为对照组。比较2组患者血清MCP-1水平,同时测定白细胞介素-18(IL-18)、C反应蛋白(CRP)水平及肺功能指标,采用Pearson方法进行相关性分析。结果:对照组血清MCP-1、IL-18及CRP水平低于病例组,第一秒钟用力呼气容积(FEV_(1))、肺一氧化碳弥散量(DLCO)、用力肺活量(FVC)高于病例组(均P<0.01)。ILD患者血清MCP-1与IL-18及CRP呈正相关(r=0.653,r=0.712,均P<0.05),与FEV_(1)、DLCO、FVC呈负相关(r=-0.581,r=-0.523,r=-0.554,均P<0.05)。结论:ILD患者血清MCP-1水平升高可能与其气道炎症和气流受限有关,在诊断ILD中具有一定的临床价值。

Objective:To explore the clinical value of serum monocyte chemoattractant protein-1(MCP-1)in the diagnosis of interstitial lung disease(ILD).Methods:Totally,80 patients with ILD were randomly selected as the case group,and 80 non-smokers in the same period were selected as the control group.Interleukin-18(IL-18),C-reactive protein(CRP)levels and pulmonary function indexes were measured and compared.The data were analyzed by SPSS20.0 software.Results:Serum levels of MCP-1,IL-18 and CRP in the control group were significantly lower than those in the patients with ILD,FEV_(1)and DLCO in the control group were significantly higher than those in the case group(all P<0.01).Serum MCP-1 in patients with ILD was positively correlated with IL-18 and CRP(r=0.653,r=0.712,P<0.05),negatively correlated with FEV_(1)and DLCO(r=-0.581,r=-0.523,r=-0.554,P<0.05).Conclusion:As one of the inflammatory markers in patients with ILD,MCP-1 is associated with airway inflammation and airflow limitation.It has certain clinical application value in the diagnosis of ILD.