超声引导下射频消融治疗胆囊息肉的疗效分析

Ultrasound-guided radiofrequency ablation for treatment of gallbladder polyps

目的探讨超声引导下射频消融治疗胆囊息肉的安全性及有效性。方法回顾性分析郑州大学第一附属医院2019年4月至2020年3月13例行超声引导下射频消融治疗胆囊息肉患者的临床资料,其中男性8例,女性5例,年龄20~49(37.2±8.4)岁。统计治疗后患者不良反应及并发症发生情况,评估息肉的完全消融率及术后病灶的吸收情况,比较患者术前及术后胆囊收缩功能。结果13例患者手术均顺利完成,术中及术后均未发生胆囊穿孔、出血及周围器官损伤等严重并发症。中位射频消融时间为30 s,完全消融率为100.0%(13/13)。患者术后1、2、3、6个月时的病灶体积缩小率分别为46.0(40.0,54.0)%、72.0(64.0,100.0)%、87.0(81.0,100.0)%、100.0(98.0,100.0)%,差异均具有统计学意义(P<0.05)。术后3个月患者胆囊收缩率(78.38±10.83)%与术前(77.46±11.28)%比较差异无统计学意义(P>0.05)。结论超声引导下射频消融治疗胆囊息肉安全且短期疗效显著,为胆囊息肉的治疗提供了一个新的临床思路。

Objective To study the safety and efficacy of ultrasound-guided radiofrequency ablation in treatment of gallbladder polyps.Methods The clinical data of 13 patients who underwent ultrasound-guided radiofrequency ablation for gallbladder polyps at the First Affiliated Hospital of Zhengzhou University from April 2019 to March 2020 were retrospectively analyzed.These were 8 males and 5 females,with ages ranging from 20 to 49 years.The incidence of adverse reactions and complications after treatment,the complete ablation rate of polyps and the absorption of postoperative lesions were studied,and the gallbladder systolic function of patients before and after treatment were compared.Results Of 13 patients,surgery was successfully carried out and there was no serious complications of gallbladder perforation,bleeding and collateral organ injury.The median radiofrequency ablation time was 30 s,and the complete ablation rate was 100.0%(13/13).After 6 months of follow-up,the rate of reduction of lesion volume was 100.0(98.0,100.0)%at 6 months after surgery,which was significantly higher than the rates of 46.0(40.0,54.0)%,72(64.0,100.0)%and 87.0(81.0±100.0)%at 1,2 and 3 months after surgery(P<0.05).The gallbladder contractility rate at 3 months after operation was(78.38±10.83)%compared with that before operation(77.46±11.28)%,and there was no significant difference(P>0.05).Conclusion Ultrasound-guided radiofrequency ablation for gallbladder polyps was safe.It had a significant short-term efficacy for treatment of gallbladder polyps.