甲氧基乙酸甲酯的合成及应用进展

Synthesis and Application of Polymethylmethacrylate

甲氧基乙酸甲酯不仅是一种合成维生素B 6、周效磺胺等药物的重要原材料,而且还是更经济合理合成乙二醇的重要原材料。当前制备工艺主要包括甲醛和甲酸甲酯偶联法、氯乙酸类和甲醇钠取代法、乙二醇单甲醚氧化法和甲缩醛羰基法。分析了制备甲氧基乙酸甲酯的方法的优缺点,综述了甲氧基乙酸甲酯在应用领域的研究进展,并对其发展趋势和应用前景作了展望。

Methyl methoxyacetateis not only an important raw material for vitamin B 6,sulfanilamide and other drugs,but also an important even more economical and reasonable raw material for ethylene glycol.Current productions include mainly formaldehyde and methyl formate coupling method,chloroacetic acid and sodium methoxide substitution method,ethylene glycol monomethyl ether oxidation method and methylal carbonyl method.The advantages and disadvantages of eachmethods,the research progress on application of methyl methoxyacetate and the developing trend,as well as prospects for future application of methyl methoxyacetate,were presented.