数据挖掘中医治疗老年高血压病用药规律

Data Mining the Medication Rule of Traditional Chinese Medicine in the Treatment of Elderly Hypertension

目的整理并总结中医治疗老年高血压病用药规律,以期为中医临床治疗本病提供理论依据和组方规律。方法收集近10年中国知网(CNKI)、万方(WangFang Data)、维普(VIP)期刊数据库中与老年高血压病相关的中药组方,对符合纳入标准的中药组方进行统计,利用WPS Excel软件建立方药数据库,应用SPSS 20.0统计软件对中药的频数、聚类规则、相关性进行分析,运用IBM SPSS Modeler 18.0统计软件对中医治疗老年高血压病用药规律进行数据挖掘,采用Cytoscpae软件绘制高频药物核心网络图。结果共获得治疗老年高血压病的中药处方119首,其中涉及中药173味,总计出现频次1548次。统计出治疗老年高血压病常用中药为活血化瘀药、补气药、平肝熄风药、补血药等,根据高频药物关联分析,挖掘出29对常用药对和12组常用药组。根据高频药物相关性分析,绘制药物核心网络图,挖掘出3组临床常用核心组方。结论中医治疗老年高血压病的病位主要在肝、脾、肾三脏,病机以肝肾不足、气血亏虚为本,可兼有风火痰瘀,治疗上主要以补益肝肾、平肝熄风、活血化瘀、燥湿化痰、健脾益气、清热降火等治疗大法为基础,常用牛膝、茯苓、天麻、黄芪、熟地黄等高频药物,临床常用核心组方有杞菊地黄丸合天麻钩藤饮加减、半夏白术天麻汤合黄连温胆汤加减及补阳还五汤加减,以上研究结果旨在为中医治疗老年高血压病提供理论依据及临床用药经验。

Objective To sort out and summarize the medication rules of traditional Chinese medicine(TCM)in the treatment of elderly hypertension,so as to provide theoretical basis and formula rules for TCM clinical treatment of this disease. Methods The TCM prescriptions related to elderly hypertension in CNKI,WangFang data and VIP journals in recent 10 years were collected,and the TCM prescriptions meeting the inclusion criteria were counted. The prescriptions database was established by WPS Excel software,and the frequency,clustering rules and correlation of TCM were analyzed by SPSS 20.0 statistical software. IBM SPSS Modeler 18.0 statistical software was used for data mining of the medication rule of TCM in the treatment of elderly hypertension,and the core network diagram of high frequency drugs was drawn by using cytoscpae software. Results A total of 119 prescriptions of traditional Chinese medicine for the treatment of elderly hypertension were obtained,including 173 herbs,with a total frequency of 1548. Statistics of the treatment of elderly hypertension,the commonly used Chinese medicine for promoting circulation blood and removing blood stasis drugs,tonifying Qi drugs,calming liver and wind drugs,tonifying blood drugs,etc. According to the high frequency drug association analysis,29 pairs of commonly used medicine pairs and 12 groups of commonly used medicine groups were excavated. According to the correlation analysis of high frequency drugs,the core network of drugs was drawn,and three groups of commonly used core prescriptions were mined. Conclusion TCM treatment of senile hypertension is mainly located in liver,spleen,kidney three viscera,pathogenesis of liver and kidney deficiency,Qi and blood deficiency as the basis,can also have wind fire phlegm stasis,treatment mainly to tonify liver and kidney,calm liver and wind,promote blood circulation and remove blood stasis,dry dampness and phlegm,invigorating spleen and Qi,clearing heat and reducing fire. High frequency drugs such as Niuxi(Achyranthis Bidentatae Radix),Fuling(Poria),Tianma(Gastrodiae Rhizoma),Huangqi(Astragali Radix),Shudihuang(Rehmanniae Radix Praeparata)are commonly used,The core prescriptions commonly used in clinical practice are Qiju Dihuang Pill(杞菊地黄丸) and Tianma Gouteng Decoction(天麻钩藤饮),Banxia Baizhu Tianma Decoction(半夏白术天麻汤)and Huanglian Wendan Decoction(黄连温胆汤),and Buyang Huanwu Decoction(补阳还五汤). The above research results aim to provide theoretical basis and clinical medication experience for the treatment of elderly hypertension by TCM.