清热养阴汤联合二甲双胍对血糖控制不佳2型糖尿病患者血液流变学、体质量指数及生活质量的影响

Effects of Qingre Yangyin Decoction (清热养阴汤) Combined with Metformin on Hemorheology, Body Mass Index and Quality of Life in Patients with Type 2 Diabetes Mellitus Inadequately Controlled

目的探讨清热养阴汤联合二甲双胍治疗血糖控制不佳2型糖尿病(T2DM)的临床疗效。方法采用随机数字表法,将2017年11月—2019年10月收治的88例血糖控制不佳T2DM患者予以分组,对照组44例,采用二甲双胍治疗,观察组44例,采用清热养阴汤联合二甲双胍治疗,对两组临床效果,治疗前,治疗6周后血糖、血液流变学、体质量指数(BMI)及生活质量变化予以观察。结果治疗总有效率观察组为90.91%(40/44),与对照组72.73%(32/44)对比,明显较高(P<0.05);治疗前,两组空腹血糖(FPG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(2hPG)对比,差异无统计学意义(P>0.05),治疗6周后,与同期对照组对比,观察组上述指标水平明显较低(P<0.05);治疗前,两组全血低切黏度(LBV)、血浆黏度(PV)、全血高切黏度(HBV)对比,差异无统计学意义(P>0.05),治疗6周后,与同期对照组对比,观察组上述指标水平明显较低(P<0.05);治疗前,两组BMI与中文版简明健康调查量表(SF-36)评分对比,无显著性差异(P>0.05),治疗6周后,与同期对照组对比,观察组上述指标情况明显较好(P<0.05)。结论清热养阴汤联合二甲双胍治疗血糖控制不佳T2DM临床效果确切,可改善患者血液流变学及BMI,提高生活质量,值得推广。

Objective To investigate the clinical efficacy of Qingre Yangyin decoction (清热养阴汤) combined with metformin in the treatment of type 2 diabetes mellitus (T2 DM) inadequately controlled. Methods Eighty-eight patients with T2 DM inadequately controlled treated from Feb 2018 to Oct 2019 were divided into groups by the random number table method. Forty-four cases in the control group were treated with metformin and those in the observation group were treated with Qingre Yangyin Decoction combined with metformin. The clinical effects, the changes of blood glucose, hemorheology, body mass index (BMI) and quality of life before and 6 weeks after treatment of two groups were observed. Results In the observation group, the total effective rate of treatment was 90.91%. Compared with that of the control group (72.73%), it was significantly higher (P<0.05). Before treatment, there were no significant differences in fasting blood glucose (FPG), glycated hemoglobin (HbA1 c) or 2 h postprandial blood glucose (2 hPG) between the two groups (P>0.05). After 6 weeks of treatment, compared with those of the control group in the same period, the levels of the above indicators in the observation group were significantly lower (P<0.05). Before treatment, there were no significant differences in low blood viscosity (LBV), plasma viscosity (PV) or high blood viscosity (HBV) between the two groups (P>0.05). After 6 weeks of treatment, compared with those of the control group in the same period, the levels of the above indicators in the observation group were significantly lower (P<0.05). Before treatment, there were no significant differences in BMI or the Chinese version 36-item short form health survey (SF-36) between the two groups (P>0.05). After 6 weeks of treatment, compared with those of the control group in the same period, the above indicators in the observation group were significantly better (P<0.05). Conclusion The clinical effect of Qingre Yangyin decoction combined with metformin in the treatment of T2 DM inadequately controlled is definite. It can relieve the hemorheology and BMI of patients and improve the quality of life, worthy of promoting.