富血小板联合三氧大自血治疗急性期带状疱疹临床效果及对炎症因子的影响

Clinical efficacy of platelet-rich plasma combined with oxygen-rich autologous blood on the treatment of acute herpes zoster and the influence on inflammatory factors

目的探讨富血小板联合三氧大自血治疗带状疱疹(HZ)急性期患者的临床效果和对血白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)因子的影响。方法选择100例确诊胸腹部急性期带状疱疹中老年患者,将符合条件的患者通过随机数字法分为对照组、富血小板组(PRP组)、三氧大自血组(三氧组)、富血小板联合三氧大自血组(联合组)4组,每组25例。比较患者不同时间VAS评分、PSQI评分、血IL-6、TNF-α因子含量、治疗30 d后加巴喷丁使用量。结果4组患者在治疗前各个时间段的VAS、PSQI量表比较差异无统计学意义(P>0.05)。与同组治疗前比较,在经有效治疗后各个时间段以上项目都明显改善且差异有统计学意义(P<0.05)。与对照组比较,PRP组、三氧组和联合组患者在每个观察时间段以上项目明显改善且差异有统计学意义(P<0.05);相比三氧组,PRP组治疗后每个观察时间段以上项目差异无统计学意义(P<0.05);联合组较PRP组、三氧组低且差异有统计学意义(P<0.05)。与同组治疗前比较,在经有效治疗后各个时间段TNF-α、IL-6都明显改善且差异有统计学意义(P<0.05)。与对照组比较,PRP组、三氧组和联合组患者在每个观察时间段TNF-α、IL-6明显改善且差异有统计学意义(P<0.05);相比三氧组,PRP组治疗后每个观察时间段TNF-α、IL-6差异无统计学意义(P>0.05);联合组较PRP组、三氧组低且差异有统计学意义(P<0.05)。联合组、PRP组、三氧组的加巴喷丁的使用剂量都少于对照组且差异有统计学意义(P<0.05);联合组的加巴喷丁服用剂量最少,与PRP组、三氧组比较差异有统计学意义(P<0.05);PRP组的加巴喷丁使用剂量比三氧组略低,但差异无统计学意义(P>0.05)。结论联合组治疗急性期带状疱疹(HZ)患者的临床效果确切,VAS评分和PSQI评分低,其与降低患者血中IL-6、TNF-α含量有关。

Objective To investigate the clinical effect of platelet-rich plasma combined with oxygen-rich autologous blood on the treatment of patients with herpes zoster(HZ)at acute stage and its influence on blood IL-6 and TNF-α.Methods 100 young and middle-aged patients with HZ in acute stage of thoracolumbar segment were selected,and randomly divided into 4 groups,control group,platelet-rich plasma group(PRP group),oxygen-rich self-blood group(oxygen-rich group),and platelet-rich combined with oxygen-rich self-blood group(combined group)(n=25).VAS score,VRS method,blood IL-6 and TNF-αfactors were compared at different times.Results The effective rate of the combined group was significantly higher than those of the other three groups,with the least dosage of gabapentin.Compared with the other three groups,the VAS score,PSQI method,IL-6 and TNF-αin the combined group were decreased after effective treatment(P<0.05).Compared with the control group,the patients in the three oxygen groups and PRP groups were significantly improved,with less dosage of gabapentin,lower VAS score and PSQI score,lower IL-6 and TNF-α.Compared with PRP group,there was no significant difference in treatment efficiency and observation items between the three oxygen groups.Conclusion The combined treatment is effective in treating patients with acute HZ,which is correlated to reducing the content of IL-6 and TNF-α.