摘要
连续性肾脏替代治疗已成为儿童肝衰竭患者的重要器官支持手段。抗凝是决定该治疗手段成功与否的关键步骤。传统的全身肝素抗凝有诱发血小板减少,引起出血的高风险;鱼精蛋白拮抗肝素局部抗凝临床效果不佳;无肝素抗凝在儿童患者尤其低体重小婴儿中很难顺利开展。近年来局部枸橼酸抗凝作为一种新型抗凝方式逐渐受到重视。本文针对这一抗凝技术的临床应用进行综述。
Continuous renal replacement therapy has become an important organ support method for children with liver failure.Anticoagulation is a key step in determining the success of this treatment.Traditional systemic heparin anticoagulation has a high risk of inducing thrombocytopenia and bleeding.Protamine antagonistic heparin local anticoagulation performance is unsatisfactory.Anticoagulation without heparin is difficult to develop smoothly in children,especially low-weight infants.In recent years,regional citrate anticoagulation has gradually received attention as a new type of anticoagulation.This article reviewed the clinical application of this anticoagulation technology.
作者
扈芳(综述)
白科
刘成军(审校)
Hu Fang;Bai Ke;Liu Chengjun(Department of PICU,Children′s Hospital of Chongqing Medical University;Ministry of Education Key Laboratory of Child Development and Disorders;National Clinical Research Center for Child Health and Disorders;China International Science and Technology Cooperation Base of Child Development and Critical Disorders;Chongqing Key Laboratory of Pediatrics,Chongqing 400014,China)
出处
《中国小儿急救医学》
CAS
2021年第4期333-336,共4页
Chinese Pediatric Emergency Medicine
基金
中华儿科百利儿科科研基金(B2016-A-3)。
关键词
肝衰竭
儿童
连续性肾脏替代治疗
局部枸橼酸抗凝
Liver failure
Children
Continuous renal replacement therapy
Regional citrate anticoagulation
