通过调控肠道菌群治疗肝性脑病的研究现状及治疗策略分析

Analysis of the research status and intervention strategies for the treatment of hepatic encephalopathy based on gut microbiota regulation

肝性脑病是终末期肝病发展过程中常见的一种代谢性神经精神异常综合征。自从肠-肝-脑轴的概念提出以来,对于肝性脑病发病过程与肠道菌群的关系一直是研究的热点。近年来肠道菌群越来越引起人们的重视,已有研究证实肠道菌群参与并影响了肝性脑病的多种病理环节。本文结合国内外的最新研究进展,针对调控肠道菌群进而干预肝性脑病病理进程的研究现状进行阐述,希望为基于肠道菌群调控干预肝性脑病进展提供新的思路与方法。

Hepatic encephalopathy is a common metabolic neuropsychiatric syndrome in the development of end-stage liver disease.Since the concept of intestinal-liver-brain axis was proposed,the relationship between the pathogenesis of hepatic encephalopathy and the gut microbiota has been a hot research topic.In recent years,studies have confirmed that gut microbiota is involved in and affects various pathological processes of hepatic encephalopathy.This article combines the latest research progress at home and abroad to elaborate on the research status of regulating gut microbiota and thus interfering with the pathological process of hepatic encephalopathy,hoping to provide new ideas and methods for the intervention of hepatic encephalopathy based on the regulation of gut microbiota.