羟基香豆素化合物合成方法的研究进展

Progress in synthetic methods of hydroxycoumarins

羟基香豆素具有良好的生物活性且应用范围广泛,是一类重要的、具有较高研究价值的化合物。近年来越来越多的新技术、新型催化剂及新方法应用到羟基香豆素的合成中,本文作者通过检索近十年国内外公开发表的关于羟基香豆素及其衍生物的文章,按照羟基取代位置的不同及使用合成方法的不同进行分类,综述了近年来4-羟基、7-羟基、4,7-二羟基及6,7-二羟基香豆素合成研究的新进展,并简要介绍了上述化合物的药理作用。

Hydroxycoumarin and its derivatives are a kind of important compounds with high research value.They not only have good biological activity,but also are important pharmaceutical intermediates.In recent years,new technologies,new catalysts and new methods are more and more applied to the synthesis of hydroxycoumarin and its derivatives,the synthetic methods are more economical,green,efficient and practical.In this paper,by searching the articles about hydroxycoumarins and their derivatives at home and abroad in recent years.Hydroxycoumarin and its derivatives were classified according to the different hydroxyl substitution positions and different synthetic methods.The new progress in the synthesis of 4-hydroxy,7-hydroxy,4,7-dihydroxy,6,7-dihydroxycoumarins and their derivatives were review ed.Their pharmacological effects were briefly introduced.