七叶皂苷钠联合非布司他治疗急性痛风性关节炎临床疗效观察

Clinical observation on sodium aescinate combined with febuxostat in treatment of acute gouty arthritis

目的观察七叶皂苷钠联合非布司他对急性痛风性关节炎患者临床疗效。方法将我院诊治的急性痛风性关节炎患者80例按治疗方案不同分为对照组(采用非布司他片治疗)与观察组(采用七叶皂苷钠联合非布司他治疗)各40例。对比两组治疗效果、血清尿酸(SUA)水平、超敏C反应蛋白(hs-crp)水平及不良反应情况。结果观察组总有效率显著高于对照组(P<0.05);治疗后,观察组视觉模拟评分(VAS)显著低于对照组(P<0.05);观察组疼痛缓解时间、水肿消除时间均明显少于对照组(P<0.05);观察组血清尿酸、C反应蛋白水平均显著低于对照组(P<0.05);两组不良反应情况无显著差异(P>0.05)。结论急性痛风性关节炎患者采用七叶皂苷钠联合非布司他治疗,能够显著提高患者临床疗效,显著降低血清尿酸浓度,且明显抑制炎症反应。

Objective To observe the clinical effect of sodium aescinate combined with febuxostat in treafment of acute gouty arthritis. Methods 80 patients with acute gouty arthritis were divided into control group and observation group,40 cases each. Control group was treated with febuxostat tablets,and observation group was treated with sodium aescinate on the basis of control group. The clinical efficacy,serum uric acid(SUA)level,hypersensitivity C-reactive protein(hs-CRP)level and adverse reactions were compared between the two groups. Results The total effective rate of observation group was significantly higher than control group(P<0.05);after treatment,the Visual analogue scale(VAS)of observation group was significantly lower than control group(P<0.05);the pain relief time and edema elimination time of observation group were significantly less than control group(P<0.05);the serum uric acid and hs-CRP levels of observation group were significantly lower than control group;there was no significant difference in adverse reactions between the two groups(P>0.05). Conclusion Sodium aescinate combined with febuxostat can significantly improve the clinical efficacy of patients with acute gouty arthritis,significantly reduce the serum uric acid concentration,and significantly inhibit the inflammatory reaction.