基于系统生物学的溃疡性结肠炎中医证候研究现状

Research on TCM syndrome of ulcerative colitis based on system biology

溃疡性结肠炎(UC)当前治疗策略能够大大改善患者临床结局,但是总体治疗效果仍远未达到最佳状态。中医药发挥整体调控,多靶点作用的优势,在UC治疗中具有显著的疗效。"证候"是中医领域研究的核心问题,但中医证候缺乏客观、量化指标制约中医学的发展和中医现代化的进程。系统生物学是一种整合性研究方法,通过研究生物系统中不同部分(基因、蛋白质、代谢物等)之间的相互关系和相互作用,从整体性、动态性、多维度的角度去解析生命活动过程及机制,其研究特点与中医药"整体观"、"辨证论治"十分契合,在中医药研究中发挥了重要作用。本文通过阐释系统生物学的UC中医证候研究现状,从系统生物学角度提出UC疾病研究的未来展望。

The current treatment strategy of ulcerative colitis(UC)can greatly improve the clinical outcomes of patients,but the overall therapeutic effect is far from optimal. TCM plays an important role in the treatment of UC."Syndrome"is the core issue in the field of TCM,but the lack of objective and quantitative indicators restricts the development and modernization of TCM. System biology is an integrated research method,by studying the relationship and interaction between different parts of the biological system(genes,proteins,metabolites,etc.),the process and mechanism of life activities are analyzed from the perspective of integrity,dynamics and multi-dimensional. The research characteristics are very consistent with the"holistic view"and"syndrome differentiation and treatment"of TCM,which plays an important role in the research of TCM. In this paper,by explaining the current situation of TCM syndrome research of UC in system biology,the future prospect of UC disease research is put forward from the perspective of system biology.