铁死亡在新生儿缺氧缺血性脑损伤中的研究进展

Research advances in the role of ferroptosis in neonatal hypoxic-ischemic brain damage

新生儿缺氧缺血性脑损伤是导致新生儿死亡和婴幼儿伤残的常见病因,但机制复杂,缺乏特异治疗手段。铁死亡作为一种新型程序性细胞死亡方式,已成为一种新的治疗靶点而逐渐在临床上引起重视。该文围绕与铁死亡及缺氧缺血性脑损伤均密切相关的铁代谢异常、胱氨酸/谷氨酸反向转运体功能异常和脂质过氧化物调控异常的研究进展进行综述。

Neonatal hypoxic-ischemic brain damage(HIBD)remains an important cause of neonatal death and disability in infants and young children,but it has a complex mechanism and lacks specific treatment methods.As a new type of programmed cell death,ferroptosis has gradually attracted more and more attention as a new therapeutic target.This article reviews the research advances in abnormal iron metabolism,glutamate antiporter dysfunction,and abnormal lipid peroxide regulation which are closely associated with ferroptosis and HIBD.