彩超引导低温等离子消融术在甲状腺良性结节的临床应用研究

A study of low-temperature plasma ablation for the treatment of benign thyroid nodules under ultrasound guidance

目的探讨彩超引导下低温等离子消融术对甲状腺良性结节治疗的临床价值。方法对36例接受彩超引导下低温等离子消融术的患者,观察术前及术后1、3、6个月甲状腺结节体积(V)、体积缩小率(VRR)及术前、术后1个月血清游离三碘甲状腺原氨酸(FT3)、血清游离甲状腺素(FT4)、促甲状腺素(TSH),评价低温等离子在治疗甲状腺良性结节的有效性及安全性。结果经过相关治疗,甲状腺良性结节术后体积逐步缩小,体积缩小率增大,差异有统计学意义[F(1.311,45.887)=378.369;P<0.001];患者术前及术后1个月TSH水平比较,差异无统计学意义(P=0.123);术前及术后1个月FT3、FT4水平比较,术后1个月的FT3、FT4较前稍升高,差异有统计学意义(P<0.001;P=0.001)。治疗过程无声嘶、饮水进食呛咳等不良并发症。结论彩超引导下低温等离子消融术治疗甲状腺良性结节安全、有效。

Objective To evaluate the clinical value of low temperature plasma ablation in the treatment of benign thyroid nodules under ultrasound-guidance. Methods 36 patients with benign thyroid nodules receiving the treatment of low temperature plasma ablation under ultrasound-guidance were randomly selected from October 2019 to October 2020. To study the volume(V), volume reduction rate(VRR) of thyroid nodule before operation and 1 month, 3 months and 6 months after operation, and serum free triiodothyronine(FT3), free thyroxine(FT4), thyrotropin(TSH) before operation and 1 month after operation, to evaluate the effectiveness and safety of low temperature plasma ablation in benign thyroid nodules under ultrasound-guidance. Results After related treatment, the volume of benign thyroid nodules gradually decreased and the volume reduction rate increased, the difference was statistically significant(F(1.311,45.887)=378.369;P<0.001);There was no statistic difference in TSH between the patients before the operation and the 1 month after treatment(P=0.123). Comparison of FT3 and FT4 before and 1 month after operation, FT3 and FT4 in 1 month after operation were slightly higher.