摘要
单羧酸转运蛋白家族(MCTs)参与肿瘤代谢调节,对细胞的乳酸、丙酮酸、酮体等物质起转运作用,在不同的肿瘤细胞中表达出不同的亚型。家族内的MCT1和MCT4及其伴侣蛋白CD147、葡萄糖转运蛋白GLUT-1、缺氧生物标记碳酸酐酶9(CAIX)在鼻咽癌、喉癌、口腔鳞状细胞癌等头颈部鳞状细胞癌中均发挥了重要作用。针对头颈鳞状细胞癌中MCTs不同的亚型采取靶向治疗及与其他治疗方式联合治疗以取得更好的疗效是未来的研究方向。就MCTs在头颈部鳞状细胞癌发生发展的作用机制及以MCTs作为靶点进行治疗的研究现状做综述。
The family of monocarboxylate transporters(MCTs) is involved in regulating tumor metabolism. Specifically, such proteins play a role in transporting lactic acid, pyruvate, ketone bodies, and other metabolites in cells. Various MCT isoforms are highly-expressed across different tumor cells. Family members MCT1 and MCT4 in conjunction with associated chaperones basigin(CD147) and glucose transporter type 1(GLUT-1), as well as the anoxia biomarker carbonic anhydrase 9(CAIX), all play important roles in head and neck squamous cell carcinomas(HNSCCs), including nasopharyngeal, laryngeal, and oral squamous cell carcinomas. Combining MCT modulation with existing therapies has the potential to improve HNSCC treatment efficacy. This review discusses the mechanisms by which MCTs contribute to development of HNSCC and the current state of research regarding MCT therapeutic targeting.
作者
马小雨(综述)
边晓敏(综述)
于丹(审校)
MA Xiaoyu;BIAN Xiaomin;YU Dan(Guidance Department of Otolaryngology&Head and Neck Surgery,The second hospital,Jilin University,Changchun130041,Jilin,China)
出处
《山东大学耳鼻喉眼学报》
CAS
2021年第2期125-130,共6页
Journal of Otolaryngology and Ophthalmology of Shandong University
基金
吉林省科技厅国际合作项目(20180414054GH)
吉林省自然科学基金(20190201212JC)
吉林大学白求恩计划项目(470110000669)
吉林省财政厅卫生人才专项基金(2019SCZT012)
吉林省财政厅项目:(JCSZ 2019378-22)。
关键词
单羧酸转运蛋白
代谢
乳酸
抑制剂
Monocarboxylate transporter
Metabolism
Lactic acid
Inhibitor
