他汀类药物所致肝功能异常及其处理策略

Liver dysfunction caused by statins and its treatment strategy

他汀类药物是临床上防治心脑血管疾病的常用药物之一。近年来,他汀类药物的使用不断呈现上升趋势,肝功能异常作为他汀类药物的主要不良反应一直备受关注,其主要表现为血清转氨酶的升高。目前他汀类药物致肝功能异常的机制主要涉及线粒体功能障碍、细胞凋亡、药物相互作用等。合理应用他汀类药物、定期监测肝功能指标、密切关注慢性肝病患者使用他汀类药物,对临床工作中正确评估和处理他汀类药物所致肝功能异常具有重要意义。

Statins are one of the commonly used drugs in the clinical prevention and treatment of cardiovascular and cerebrovascular diseases. In recent years, the use of statins continues to show an upward trend. Abnormal liver function, as the main adverse reaction of statins, has been attracted attention, which is mainly manifested as an increase in serum transaminase. At present, the mechanisms of abnormal liver function caused by statins mainly include mitochondrial dysfunction, apoptosis, and drug interactions. Reasonable application of statins, regular monitoring of liver function indicators, and paying close attention to the use of statins in patients with chronic liver diseases are of great significance to the correct evaluation and treatment of abnormal liver function caused by statins in clinical work.